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Original ArticlePharmacognosy MagazineVol. 18 | Issue 80 | 2022 | pp. 1055–1065Open access
Exploring the Beneficial Role of Ononin in Preventing Ovariectomy‑Induced Osteoporosis In Rats Via Osx And Runx2 Pathway
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- 2,4,
- 5,
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- 2,5*
- 1 Clinical College of Orthopedics, Tianjin Medical University, Tianjin.
- 2 Department of Orthopedic, The Third Central Hospital of Tianjin, Tianjin.
- 3 Department of Orthopedic, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology Baotou, Inner Mongolia.
- 4 Department of Minimally Invasive Spine Surgery, Tianjin Hospital, Jiefang South Road 406, Hexi District, Tianjin.
- 5 Graduate School, Tianjin Medical University, Tianjin, China ¶Equal contribution.
Published in Pharmacognosy Magazine
Correspondence: BaoShan Xu
Department of Orthopedic, The Third Central Hospital of Tianjin, Tianjin.; Graduate School, Tianjin Medical University, Tianjin, China ¶Equal contribution.
Email: baoshanxu99@tmu.edu.cn
Copyright: © 2022 Manuscript Technomedia. This is an open access article.
- Published:
- Nov 23, 2022
- Received:
- Jun 25, 2021
- Accepted:
- Aug 1, 2022
- DOI:
- 10.4103/pm.pm_282_21
How to cite
Wang¶, T., Tian¶, L., Du, L., Li, G., Li, Y., & Xu, B. (2022). Exploring the Beneficial Role of Ononin in Preventing Ovariectomy‑Induced Osteoporosis In Rats Via Osx And Runx2 Pathway. Pharmacognosy Magazine, 18(80), 1055–1065. https://doi.org/10.4103/pm.pm_282_21
Abstract
Objectives: In this study, we aimed to evaluate the efficacy of ononin against ovariectomy(OVX)‑induced osteoporosis in female rats. Materials and Methods: Ovaries were removed surgically to develop the animal model of OVX. Animals (n = 4) were grouped into control, OVX induced, OVX rats treated with ononin (10 mg/kg body weight), and OVX rats treated with 20 mg/kg body weight of ononin. Results: OVX rats treated with ononin showed improved body weight, uterus index, inflammatory and bone markers, serum lipid profile, and calcium level. Ononin downregulated the expression of estrogen (E2), acid phosphatase, and bone gamma‑carboxyglutamate (Gla) protein in OVX rats. It also restored trabecular area and thickness, which was evidenced by histomorphometrical and histopathological examination. Ononin attenuated the expression of alkaline phosphatase, osterix, and Runx2 in OVX rats. Conclusion: In summary, our results suggest that ononin could be used as an ideal therapeutic agent to prevent and treat bone‑associated disorders.
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Article metadata
| Title | Exploring the Beneficial Role of Ononin in Preventing Ovariectomy‑Induced Osteoporosis In Rats Via Osx And Runx2 Pathway |
|---|---|
| Authors | Tonghao Wang¶; Lijun Tian¶; Lilong Du; Guowang Li; Yongjin Li; BaoShan Xu |
| Affiliations | Clinical College of Orthopedics, Tianjin Medical University, Tianjin.; Department of Orthopedic, The Third Central Hospital of Tianjin, Tianjin.; Department of Orthopedic, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology Baotou, Inner Mongolia.; Department of Minimally Invasive Spine Surgery, Tianjin Hospital, Jiefang South Road 406, Hexi District, Tianjin.; Graduate School, Tianjin Medical University, Tianjin, China ¶Equal contribution. |
| Corresponding author | baoshanxu99@tmu.edu.cn |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 18, Issue 80 (2022) |
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