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Original ArticlePharmacognosy ResearchVol. 8 | Issue 2 | 2016 | pp. 142–146Open access
Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae)
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- 1 Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA)
- 2 Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM)
- 3 Laboratoire de Physiologie et de Pharmacologie, Faculté des Sciences, Université de Lomé, B.P. 1515
- 4 Centre de Recherche en Agriculture Biologique et Substances Naturelles (CRABISNA)
Published in Pharmacognosy Research
Correspondence: Kokou Anani
Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA); Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM); Centre de Recherche en Agriculture Biologique et Substances Naturelles (CRABISNA)
Email: kokouanani@gmail.com
Copyright: © 2016 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2016
How to cite
Anani, K., Adjrah, Y., Améyapoh, Y., Karou, S. D., Agbonon, A., Souza, C. D., & Gbeassor, M. (2016). Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae). Pharmacognosy Research, 8(2), 142–146. https://doi.org/10.4103/0974-8490.172657
Abstract
Background
Jatropha multifida is used in Togolease folk medicine for the healing of chronic wounds.
Objective
This study aims to investigate antibacterial, anti-inflammatory and antioxidant activities of the leaves ethanolic extract.
Materials and Methods
The antimicrobial activity was assayed by National Committee for Clinical Laboratory Standards broth microdilution method on strains of Staphylococcus aureus and Pseudomoas aeruginosa isolated from wounds, whereas the anti-inflammatory activity was performed by carrageenan and histamine induced paw edema method in rat modele. The 2, 2-diphenyl- 1picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) were used for the antioxidant activity.
Results
The antibacterial assay showed an in vitro growth inhibition of P. aeruginosa and S. aureus in dose-dependent manner, with minimum inhibitory concentration values ranging from 2.5 to 3.12 mg/mL for S. aureus and from 6.25 to 12.5 mg/mL for P. aeruginosa. The maximum paw anti-inflammatory effect occurred after 3 and 5 h administration of histamine and carrageenan, respectively. The DPPH radical scavenging and the FRAP assays yielded weak antioxidant activity.
Conclusion
J. multifida possesses antibacterial and anti-inflammatory activities that could justify the use of the plant for the treatment of wounds in the folk medicine.
Keywords
Subject
Article metadata
| Title | Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae) |
|---|---|
| Authors | Kokou Anani; Yao Adjrah; Yaovi Améyapoh; Simplice Damintoti Karou; Amegnona Agbonon; Comlan de Souza; Messanvi Gbeassor |
| Affiliations | Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA); Centre de Recherche et de Formation sur les Plantes Médicinales (CERFOPLAM); Laboratoire de Physiologie et de Pharmacologie, Faculté des Sciences, Université de Lomé, B.P. 1515; Centre de Recherche en Agriculture Biologique et Substances Naturelles (CRABISNA) |
| Corresponding author | kokouanani@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 8, Issue 2 (2016) |
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