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Original ArticlePharmacognosy ResearchVol. 8 | Issue 4 | 2016 | pp. 253–257Open access
Chemical Characterization and Cytoprotective Effect of the Hydroethanol Extract from Annona coriacea Mart. (Araticum)
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- 1 Department of Biotechnology, Ceará State University, Fortaleza (CE)
- 2 Department of Biological Chemistry, Regional University of Cariri, Crato (CE)
- 3 Department of Biomedicine, Leão Sampaio College, Juazeiro do Norte (CE)
- 4 Department of Medical Microbiology, Federal University of Ceará, Fortaleza (CE)
- 5 Department of Medicine, Medical School of Juazeiro do Norte - Estacio, Juazeiro do Norte (CE)
- 6 Department of Health, University of Fortaleza – UNIFOR, Fortaleza (CE) Brazil
Published in Pharmacognosy Research
Correspondence: Henrique D. M. Coutinho
Department of Biological Chemistry, Regional University of Cariri, Crato (CE)
Email: hdmcoutinho@gmail.com
Copyright: © 2016 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2016
How to cite
Júnior, J. G. A. S., Coutinho, H. D. M., Boris, T. C. C., Cristo, J. S., Pereira, N. L. F., Figueiredo, F. G., Cunha, F. A. B., Aquino, P. E. A., Nascimento, P. A. C., Mesquita, F. J. C., Moreira, P. H. F., Coutinho, S. T. B., Souza, I. T., Teixeira, G. C., Ferreira, N. M. N., Farina, E. O., Torres, C. M. G., Holanda, V. N., Pereira, V. S., & Guedes, M. I. F. (2016). Chemical Characterization and Cytoprotective Effect of the Hydroethanol Extract from Annona coriacea Mart. (Araticum). Pharmacognosy Research, 8(4), 253–257. https://doi.org/10.4103/0974-8490.188882
Abstract
Introduction
Annona coriacea Mart. (araticum) is a widely distributed tree in the cerrado. Its value is attributed principally to the consumption of its fruit which possesses a large nutritive potential. The objective was to identify the chemical profile and evaluate the antimicrobial and cytoprotective activity of the hydroethanol extract of A. coriacea Mart. (HEAC) leaves against the toxicity of mercury chloride.
Materials and Methods
The characterization of components was carried out using high-performance liquid chromatography (HPLC). The minimum inhibitory concentration (MIC) was determined by microdilution method in broth with strains of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. For evaluation of the modulatory and cytoprotective activity of aminoglycoside antibiotics (gentamicin and amikacin) and mercury chloride (HgCl2), the substances were associated with the HEAC at subinhibitory concentrations (MIC/8).
Results and Discussion
The HPLC analysis revealed the presence of flavonoids such as Luteolin (1.84%) and Quercetin (1.19%) in elevated concentrations. The HEAC presented an MIC ≥512 mg/mL and significant antagonistic action in aminoglycosides modulation, and it also showed cytoprotective activity to S. aureus (significance P < 0.0001) and E. coli (significance P < 0.05) bacteria against the mercury chloride heavy metal with significance, this action being attributed to the chelating properties of the flavonoids found in the chemical identification.
Conclusions
The results acquired in this study show that the HEAC presents cytoprotective activity over the tested strains in vitro and can also present antagonistic effect when associated with aminoglycosides, reinforcing the necessity of taking caution when combining natural and pharmaceutical products.
Keywords
Subject
Article metadata
| Title | Chemical Characterization and Cytoprotective Effect of the Hydroethanol Extract from Annona coriacea Mart. (Araticum) |
|---|---|
| Authors | José G. A. S. Júnior; Henrique D. M. Coutinho; Ticiana C. C. Boris; Janyketchuly S. Cristo; Nara L. F. Pereira; Fernando G. Figueiredo; Francisco A. B. Cunha; Pedro E. A. Aquino; Polyana A. C. Nascimento; Francisco J. C. Mesquita; Paulo H. F. Moreira; Sáskia T. B. Coutinho; Ivon T. Souza; Gabriela C. Teixeira; Najla M. N. Ferreira; Eleonora O. Farina; Cícero M. G. Torres; Vanderlan N. Holanda; Vandbergue S. Pereira; Maria I. F. Guedes |
| Affiliations | Department of Biotechnology, Ceará State University, Fortaleza (CE); Department of Biological Chemistry, Regional University of Cariri, Crato (CE); Department of Biomedicine, Leão Sampaio College, Juazeiro do Norte (CE); Department of Medical Microbiology, Federal University of Ceará, Fortaleza (CE); Department of Medicine, Medical School of Juazeiro do Norte - Estacio, Juazeiro do Norte (CE); Department of Health, University of Fortaleza – UNIFOR, Fortaleza (CE) Brazil |
| Corresponding author | hdmcoutinho@gmail.com |
| Journal | Pharmacognosy Research |
| Volume / Issue | Vol. 8, Issue 4 (2016) |
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