Pharmacological Studies on ‘Clove’ Eugenia caryophyllata

Al-Mofleh, I.A.; Alhaider, A.A.; Mossa, J.S.; Al-Sohaibani, M.O.; Qureshi, S.; Rafatullah, S.

Research ArticlePharmacognosy MagazineVol. 1 | Issue 3 | 2005 | pp. 105–106Open access

Pharmacological Studies on ‘Clove’ Eugenia caryophyllata

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¹ Gastroenterology Unit (59), College of Medicine & KKUH, King Saud University, P.O. Box 2925, Riyadh-11461, Saudi Arabia.
² Department of Pharmacognosy and Pharmacology, Medicinal, Aromatic and Poisoning Plants Research Center, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia.
³ Department of Pathology (32), College of Medicine & KKUH, King Saud University, P.O. Box 2925, Riyadh-11461, Saudi Arabia.

Correspondence: I.A. Al-Mofleh
Gastroenterology Unit (59), College of Medicine & KKUH, King Saud University, P.O. Box 2925, Riyadh-11461, Saudi Arabia.

Published:: Jan 1, 2005

How to cite

Al-Mofleh, I., Alhaider, A., Mossa, J., Al-Sohaibani, M., Qureshi, S., & Rafatullah, S. (2005). Pharmacological Studies on ‘Clove’ Eugenia caryophyllata. Pharmacognosy Magazine, 1(3), 105–106.

Abstract

An aqueous suspension of clove, Eugenia caryophyllata (Spreng.) (Myrtaceae) was tested for its ability to inhibit basal gastric secretion and to protect gastric mucosa against the injuries caused by pyloric ligation, indomethacin and cytodestructive agents (80% ethanol, 0.2 M NaOH and 25% NaCl) in rats. The suspension in doses of 250 and 500 mg/kg body weight had a significant antiulcerogenic activity on the models used. Besides, ethanol-induced depleted non-protein sulfhydryl (NP-SH) and gastric wall mucus contents were replenished by pretreatment with clove suspension. No significant histopathological changes are noted. In acute, chronic and genotoxicity tests clove suspension showed a large margin of safety in the animals and did not induce any significant changes in the micronucleated polychromatic erythrocytes (PCE) and the ratio of PCE and normochromatic erythrocytes (NCE) at both doses used, as compared to control group, suggesting lack of any significant clastogenic and/or cytotoxic potentials.

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Article metadata

Title	Pharmacological Studies on ‘Clove’ Eugenia caryophyllata
Authors	I.A. Al-Mofleh; A.A. Alhaider; J.S. Mossa; M.O. Al-Sohaibani; S. Qureshi; S. Rafatullah
Affiliations	Gastroenterology Unit (59), College of Medicine & KKUH, King Saud University, P.O. Box 2925, Riyadh-11461, Saudi Arabia.; Department of Pharmacognosy and Pharmacology, Medicinal, Aromatic and Poisoning Plants Research Center, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh-11451, Saudi Arabia.; Department of Pathology (32), College of Medicine & KKUH, King Saud University, P.O. Box 2925, Riyadh-11461, Saudi Arabia.
Journal	Pharmacognosy Magazine
Volume / Issue	Vol. 1, Issue 3 (2005)