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Original ArticlePharmacognosy MagazineVol. 10 | Issue 38 | 2014 | pp. 161–164Open access
Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells
- 2,
- 2,
- 2,
- 2,
- 2*
- 1 Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University.
- 2 Research Institute of Biotechnology, Kangwon National University, Chuncheon, Korea.
Published in Pharmacognosy Magazine
Correspondence: Choong Je Ma
Research Institute of Biotechnology, Kangwon National University, Chuncheon, Korea.
Email: cjma@kangwon.ac.kr
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 17, 2014
- Received:
- Sep 27, 2012
How to cite
Weon, J. B., Lee, B., Yun, B. R., Lee, J., & Ma, C. J. (2014). Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells. Pharmacognosy Magazine, 10(38), 161–164. https://doi.org/10.4103/0973-1296.131028
Abstract
Background: Cynanchum paniculatum, belongs to the family Asclepiadaceae and is used to treat various diseases, such as invigorate blood, alleviate edema and to relieve pain and toxicity for a long time. Materials and Methods: 4,5-Dimethoxypyrocatechol was isolated from the 80% methanol extract of C. paniculatum and its neuroprotective effect was evaluated by MTT assay. Results: 4,5-Dimethoxypyrocatechol had neuroprotective effect on the glutamate-induced cellular oxidative death in HT22 cells. Conclusion: Furthermore, we found that reactive oxygen species (ROS) accumulation and calcium concentration by oxidative stress were reduced by 4,5-dimethoxypyrocatechol in HT22 cells.
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Article metadata
| Title | Neuroprotective effects of 4,5-dimethoxypyrocatechol isolated from Cynanchum paniculatum on HT22 cells |
|---|---|
| Authors | Jin Bae Weon; Bohyoung Lee; Bo-Ra Yun; Jiwoo Lee; Choong Je Ma |
| Affiliations | Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University.; Research Institute of Biotechnology, Kangwon National University, Chuncheon, Korea. |
| Corresponding author | cjma@kangwon.ac.kr |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 10, Issue 38 (2014) |
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