Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 10 | Issue 38s | 2014 | pp. 214–216Open access
Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues
- 1*,
- 2,
- 2,
- 2
- 1 Ordu University Centre Research Laboratory, Ordu, Turkey.
- 2 Departments of Medical Biochemistry and, University Centre Research Laboratory, Ordu, Turkey.
- 3 Surgical Oncology, Ankara University Faculty of Medicine, Ankara, Turkey.
Published in Pharmacognosy Magazine
Correspondence: Zahide Esra Durak
Ordu University Centre Research Laboratory, Ordu, Turkey.
Email: ilker_durak@yahoo.com
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- May 28, 2014
- Received:
- Jul 5, 2013
How to cite
Durak, Z. E., Büber, S., Devrim, E., & Durak, H. K. İ. (2014). Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues. Pharmacognosy Magazine, 10(38s), 214–216. https://doi.org/10.4103/0973-1296.133232
Abstract
Objective: To investigate possible effects of aqueous taxus baccata extract on adenosine deaminase (ADA) activity in cancerous and noncancerous human tissues and to clarify mechanism(s) of its anticancer potential. Materials and Methods: Cancerous and noncancerous human gastric and colon tissues were used in the study. The extracts were prepared in distilled water. Before and after treatment with the extracts, ADA activities in the tissue homogenates were measured. Results: ADA activity was found to be higher in gastric tissue compared with colon tissue, but no differences were found between ADA activities of cancerous and noncancerous tissues for both as well. In the plant extract studies, it was found that taxus extract significantly inhibited ADA activity both in cancerous and noncancerous gastric and colon tissues. Conclusion: Our results suggest that aqueous extract from taxus baccata inhibits ADA activities in both gastric and colon tissues significantly. It is suggested that in addition to other proposed mechanisms, accumulated adenosine due to the inhibition of ADA enzyme might also play part in the anticancer properties of taxus species.
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Article metadata
| Title | Aqueous extract from taxus baccata inhibits adenosine deaminase activity significantly in cancerous and noncancerous human gastric and colon tissues |
|---|---|
| Authors | Zahide Esra Durak; Süleyman Büber; Erdinç Devrim; Hilmi Kocaoğlu2, İlker Durak |
| Affiliations | Ordu University Centre Research Laboratory, Ordu, Turkey.; Departments of Medical Biochemistry and, University Centre Research Laboratory, Ordu, Turkey.; Surgical Oncology, Ankara University Faculty of Medicine, Ankara, Turkey. |
| Corresponding author | ilker_durak@yahoo.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 10, Issue 38s (2014) |
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