Open access · Peer reviewed · No APCs
Pharmacognosy MagazineVol. 11 | Issue 41 | 2015 | pp. 143–146Open access
Effects of aqueous extract from Silybum marianum on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissues
- 1*,
- 2,
- 3
- 1 Department of Medical Biochemistry, Faculty of Medicine, Selcuk University, Konya, Turkey.
- 2 Department of Surgical Oncology, Faculty of Medicine, Ankara University, Turkey.
- 3 Central Research Laboratory, Ordu University, Ordu, Turkey.
Published in Pharmacognosy Magazine
Correspondence: Bahadır Öztürk
Department of Medical Biochemistry, Faculty of Medicine, Selcuk University, Konya, Turkey.
Email: ozturkbhdr@hotmail.com
Copyright: © 2015 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2015
- Received:
- Dec 2, 2013
How to cite
Öztürk, B., Kocaoğlu, E. H., & Durak, Z. E. (2015). Effects of aqueous extract from Silybum marianum on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissues. Pharmacognosy Magazine, 11(41), 143–146. https://doi.org/10.4103/0973-1296.149729
Abstract
Objective: Investigation of possible effects of Silybum marianum extract (SME) on adenosine deaminase (ADA) activity in cancerous and noncancerous human gastric and colon tissues to obtain information about possible mechanism of anticancer action of S. marianum. Materials and Methods: Cancerous and noncancerous human gastric and colon tissues removed from patients by surgical operations were used in the studies. The extract was prepared in distilled water. Before and after treatment with the extract, ADA activities in the samples were measured. Results: ADA activity was found to be lowered significantly in cancerous gastric tissues but not in noncancerous gastric tissues after treatment with the SME. In the colon tissues, ADA activities were however found to increase after the treatment of SME. Conclusion: Our results suggest that the aqueous extract from S. marianum inhibits ADA activity in cancerous gastric tissues significantly. It is suggested that in addition to other proposed mechanisms, accumulated adenosine due to the inhibition of ADA might also play a part in the anticancer properties of the S. marianum.
Keywords
Article metadata
| Title | Effects of aqueous extract from Silybum marianum on adenosine deaminase activity in cancerous and noncancerous human gastric and colon tissues |
|---|---|
| Authors | Bahadır Öztürk; Ender Hilmi Kocaoğlu; Zahide Esra Durak |
| Affiliations | Department of Medical Biochemistry, Faculty of Medicine, Selcuk University, Konya, Turkey.; Department of Surgical Oncology, Faculty of Medicine, Ankara University, Turkey.; Central Research Laboratory, Ordu University, Ordu, Turkey. |
| Corresponding author | ozturkbhdr@hotmail.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 11, Issue 41 (2015) |
Also in this issue
- Simultaneous determination of nine analytes in Clausena harmandiana Pierre. by new developed high‑performance liquid chromatography method and the influence of locations in Thailand on level of nordentatin and dentatinpp. 1–7
- Near-infrared for on-line determination of quality parameter of Sophora japonica L. (formula particles): From lab investigation to pilot-scale extraction processpp. 8–9
- Flavonoid profiles of three Bupleurum species and in vitro hepatoprotective activity of Bupleurum flavum Forsk.pp. 14–23
- Hepatoprotective and antibacterial activity of Lippia nodiflora Linn. against lipopolysaccharides on HepG2 cellspp. 24–31
- Peptides from two sanguinovorous leeches analyzed by ultra‑performance liquid chromatography coupled with electrospray ionization quadrupole time‑of‑flight mass spectrometric detectorpp. 32–37
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026