Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 10 | Issue 39s | 2014 | pp. 501–505Open access
New steroidal saponin from Antigonon leptopus Hook. and Arn.
- 1,
- 1*
- 1 Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines.
Published in Pharmacognosy Magazine
Correspondence: Christine L. Chichioco‑Hernandez
Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines.
Email: cchernandez@upd.edu.ph
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2014
- Received:
- Oct 12, 2013
How to cite
Apaya, M. K. L., & Chichioco‑Hernandez, C. L. (2014). New steroidal saponin from Antigonon leptopus Hook. and Arn. Pharmacognosy Magazine, 10(39s), 501–505. https://doi.org/10.4103/0973-1296.139781
Abstract
Background: Antigonon leptopus Hook. and Arn., Polygonaceae (cadena de amor), is a herbal remedy for pain and gout-like symptoms in the Philippines. The methanol extract of A. leptopus have shown strong inhibitory action against xanthine oxidase. Objective: To isolate and identify the compound responsible for the xanthine oxidase inhibitory action. Materials and Methods: A bioassay-guided isolation scheme using an in vitro assay for the inhibition of xanthine oxidase was employed. The structure was established using spectroscopic analysis and chemical methods. Results: The isolated compound was determined to be a noncompetitive inhibitor of xanthine with an IC50 of 1.79 μg/mL. Conclusion: The isolated compound may represent a new class of xanthine oxidase inhibitors.
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Article metadata
| Title | New steroidal saponin from Antigonon leptopus Hook. and Arn. |
|---|---|
| Authors | Maria Karmella L. Apaya; Christine L. Chichioco‑Hernandez |
| Affiliations | Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines. |
| Corresponding author | cchernandez@upd.edu.ph |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 10, Issue 39s (2014) |
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