Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 10 | Issue 39s | 2014 | pp. 501–505Open access
New steroidal saponin from Antigonon leptopus Hook. and Arn.
- 1,
- 1*
- 1 Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines.
Published in Pharmacognosy Magazine
Correspondence: Christine L. Chichioco‑Hernandez
Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines.
Email: cchernandez@upd.edu.ph
Copyright: © 2014 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2014
- Received:
- Oct 12, 2013
How to cite
Apaya, M. K. L., & Chichioco‑Hernandez, C. L. (2014). New steroidal saponin from Antigonon leptopus Hook. and Arn. Pharmacognosy Magazine, 10(39s), 501–505. https://doi.org/10.4103/0973-1296.139781
Abstract
Background: Antigonon leptopus Hook. and Arn., Polygonaceae (cadena de amor), is a herbal remedy for pain and gout-like symptoms in the Philippines. The methanol extract of A. leptopus have shown strong inhibitory action against xanthine oxidase. Objective: To isolate and identify the compound responsible for the xanthine oxidase inhibitory action. Materials and Methods: A bioassay-guided isolation scheme using an in vitro assay for the inhibition of xanthine oxidase was employed. The structure was established using spectroscopic analysis and chemical methods. Results: The isolated compound was determined to be a noncompetitive inhibitor of xanthine with an IC50 of 1.79 μg/mL. Conclusion: The isolated compound may represent a new class of xanthine oxidase inhibitors.
Keywords
Subject
Article metadata
| Title | New steroidal saponin from Antigonon leptopus Hook. and Arn. |
|---|---|
| Authors | Maria Karmella L. Apaya; Christine L. Chichioco‑Hernandez |
| Affiliations | Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines. |
| Corresponding author | cchernandez@upd.edu.ph |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 10, Issue 39s (2014) |
Also in this issue
- High performance liquid chromatography profiling of health‑promoting phytochemicals and evaluation of antioxidant, anti‑lipoxygenase, iron chelating and anti‑glucosidase activities of wetland macrophytespp. 443–455
- Chemical constituents and toxicological studies of leaves from Mimosa caesalpiniifolia Benth., a Brazilian honey plantpp. 456–462
- Anti‑melanogenic activity of the novel herbal medicine, MA128, through inhibition of tyrosinase activitypp. 463–471
- Ultra high performance liquid chromatography‑ ultraviolet‑electrospray ionization‑micrOTOF‑Q II analysis of flavonoid fractions from Jatropha tanjorensispp. 472–479
- Multiple shoot regeneration and effect of sugars on growth and nitidine accumulation in shoot cultures of Toddalia asiaticapp. 480–486
Readers Also Viewed
Effect of the Fractions of Coccinia grandis on Ethanol- Induced Cerebral Oxidative Stress in Rats
M. Umamaheswari, T. K. Chatterjee
Jan 1, 2009
Phytochemical Screening and Antioxidant Activity Evaluation of Selected Philippine Fruit Peels and Pulps
Mildred Dagcuta Pates, Angelo Mark Po Walag, Romeo M. Del Rosario
Aug 17, 2026
Impact of Artificial Intelligence Assisted Drug Therapy Optimization on Drug Related Problems Amongst Older Adult Patients: A Systematic Review
Jehath Syed, Christy Thomas, Bavneet Kaur
Oct 23, 2026