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Original ArticlePharmacognosy MagazineVol. 12 | Issue 46s | 2016 | pp. S223–S227Open access
Phytochemicals from Tradescantia albiflora Kunth Extracts Reduce Serum Uric Acid Levels in Oxonate-induced Rats
- 2,3,
- 4,5,6,
- 7,
- 8,
- 9,
- 10,
- 11,12,
- 13,14*,
- 2,15,16*,
- 8*
- 1 School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taiwan.
- 2 Department of Chinese Internal Medicine, China Medical University Hospital, Taiwan.
- 3 School of Medicine, Chung Shan Medical University, Taiwan.
- 4 Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Departments of, Taiwan.
- 5 Occupational Therapy, Taiwan.
- 6 Agronomy and, Taiwan.
- 7 School of Veterinary Medicine, National Taiwan University, Taiwan.
- 8 Chemistry, National Taiwan University, Taiwan.
- 9 Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan.
- 10 Department of Chinese Medicine, Buddhist Tzu Chi General Hospital, Taichung Branch, Departments of, Taiwan.
- 11 School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Departments of, Taiwan.
- 12 Chinese Pharmaceutical Sciences and Chinese Medicine Resources and, Taiwan.
- 13 Biotechnology, Taiwan.
- 14 Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
- 15 Biomedical Informatics and, Taiwan.
- 16 Post-Baccalaureate Veterinary Medicine, Asia University, Taiwan.
Published in Pharmacognosy Magazine
Correspondence: Yueh-Hsiung Kuo
Biotechnology, Taiwan.; Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
Email: Kuoyh@mail.cmu.edu.tw
Correspondence: Chun-Hsu Yao
Department of Chinese Internal Medicine, China Medical University Hospital, Taiwan.; Biomedical Informatics and, Taiwan.; Post-Baccalaureate Veterinary Medicine, Asia University, Taiwan.
Email: chyao@mail.cmu.edu.tw
Correspondence: Tzong-Fu Kuo
Chemistry, National Taiwan University, Taiwan.
Email: tzongfu@ntu.edu.tw
Copyright: © 2016 Manuscript Technomedia. This is an open access article.
- Published:
- May 11, 2016
- Received:
- Oct 11, 2015
How to cite
Wang, W. L., Sheu, S. Y., Huang, W. D., Chuang, Y. L., Tseng, H. C., Hwang, T. S., Fu, Y. T., Kuo, Y. H., Yao, C. H., & Kuo, T. F. (2016). Phytochemicals from Tradescantia albiflora Kunth Extracts Reduce Serum Uric Acid Levels in Oxonate-induced Rats. Pharmacognosy Magazine, 12(46s), S223–S227. https://doi.org/10.4103/0973-1296.182171
Abstract
Background: Tradescantia albiflora (TA) Kunth (Commelinaceae) has been used for treating gout and hyperuricemia as folklore remedies in Taiwan. Therefore, it is worthwhile to study the effect of TA extracts on lowering uric acid activity. The hypouricemic effects of TA extracts on potassium oxonate (PO)‑induced acute hyperuricemia were investigated for the first time. Materials and Methods: All treatments at the same volume (1 ml) were orally administered to the abdominal cavity of PO‑induced hyperuricemic rats. One milliliter of TA extract in n-hexane (HE), ethyl acetate (EA), n-butanol (BuOH), and water fractions has 0.28, 0.21, 0.28, and 1.03 mg TA, respectively; and the plasma uric acid (PUA) level was measured for a consecutive 4 h after administration. Results: All four fractions’ extracts derived from TA were observed to significantly reduce PUA compared with the PO group. The EA‑soluble fraction (TA‑EA) exhibited the best xanthine oxidase (XO) inhibitory activity. Following column chromatography, 12 phytochemicals were isolated and identified from the EA fraction. The IC50 values of isolated phytochemicals indicated that bracteanolide A (AR11) showed the remarkable XO inhibitory effect (IC50 value of 76.4 µg/ml). These findings showed that the in vivo hypouricemic effect in hyperuricemic rats was consistent with in vitro XO inhibitory activity, indicating that TA extracts and derived phytochemicals could be potential candidates as hypouricemic agents.
Keywords
Subject
Article metadata
| Title | Phytochemicals from Tradescantia albiflora Kunth Extracts Reduce Serum Uric Acid Levels in Oxonate-induced Rats |
|---|---|
| Authors | Wen-Ling Wang; Shi-Yuan Sheu; Wen-Dar Huang; Ya-Ling Chuang; Han-Chun Tseng; Tzann-Shun Hwang; Yuan-Tsung Fu; Yueh-Hsiung Kuo; Chun-Hsu Yao; Tzong-Fu Kuo |
| Affiliations | School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taiwan.; Department of Chinese Internal Medicine, China Medical University Hospital, Taiwan.; School of Medicine, Chung Shan Medical University, Taiwan.; Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Departments of, Taiwan.; Occupational Therapy, Taiwan.; Agronomy and, Taiwan.; School of Veterinary Medicine, National Taiwan University, Taiwan.; Chemistry, National Taiwan University, Taiwan.; Graduate Institute of Biotechnology, Chinese Culture University, Taipei, Taiwan.; Department of Chinese Medicine, Buddhist Tzu Chi General Hospital, Taichung Branch, Departments of, Taiwan.; School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Departments of, Taiwan.; Chinese Pharmaceutical Sciences and Chinese Medicine Resources and, Taiwan.; Biotechnology, Taiwan.; Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.; Biomedical Informatics and, Taiwan.; Post-Baccalaureate Veterinary Medicine, Asia University, Taiwan. |
| Corresponding author | Kuoyh@mail.cmu.edu.tw |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 12, Issue 46s (2016) |
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