Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 12 | Issue 46s | 2016 | pp. S201–S205Open access
S201 Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1
- 1*,
- 1*,
- 1*,
- 3,
- 3,
- 2,
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- 1 Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250000.
- 2 Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Jiangsu Province Key Laboratory of Anesthesiology and Center for Pain Research and Treatment.
- 3 Department of Anesthesiology, Xuzhou Central Hospital, Jiangsu 221002, PR China Pharmacogn. Mag. A multifaceted peer reviewed journal in the field of Pharmacognosy and Natural Products.
Published in Pharmacognosy Magazine
Correspondence: Wei Cheng
Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250000.
Email: zhijian_fu@126.com
Correspondence: Jin‑Feng Wang
Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250000.
Email: zhijian_fu@126.com
Correspondence: Cong‑Xian Yang
Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250000.
Email: zhijian_fu@126.com
Correspondence: Zhi‑Jian Fu
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Jiangsu Province Key Laboratory of Anesthesiology and Center for Pain Research and Treatment.
Email: zhijian_fu@126.com
Copyright: © 2016 Manuscript Technomedia. This is an open access article.
- Published:
- May 11, 2016
- Received:
- Aug 29, 2015
How to cite
Cheng, W., Wang, J., Yang, C., Wu, L., Yin, Q., Liu, H., & Fu, Z. (2016). S201 Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1. Pharmacognosy Magazine, 12(46s), S201–S205. https://doi.org/10.4103/0973-1296.182167
Abstract
Objective: The present study sought to detect spinal sirtuin 1 (SIRT1) and acetylation of histone H3 (Ac‑H3) expression in rats with burn injury pain (BIP model). Procedures and Results: A BIP model was first established. BIP rats showed lower paw withdrawal threshold (PWT) from day 1, which persisted for 21 days following the burn injury. Spinal SIRT1/Ac‑H3 expression increased following burn injury. The intrathecal use of resveratrol increased PWT and SIRT1 expression but induced down‑regulation of Ac‑H3 expression. We first demonstrated that the inhibition of SIRT1 significantly induced mechanical allodynia in naïve rats. The preinjection of SIRT1 inhibitor partly antagonized the analgesic effects of resveratrol in BIP rats. Conclusion: Inhibition of SIRT1 produces pain facilitation in the naïve rats. The expression of spinal SIRT1 increased after burn injury in the BIP model. The activation of spinal SIRT1 might mediate the resveratrol‑induced analgesic effects.
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Article metadata
| Title | S201 Intrathecal Injection of Resveratrol Attenuates Burn Injury Pain by Activating Spinal Sirtuin 1 |
|---|---|
| Authors | Wei Cheng; Jin‑Feng Wang; Cong‑Xian Yang; Liang Wu; Qin Yin; He Liu; Zhi‑Jian Fu |
| Affiliations | Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250000.; Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Jiangsu Province Key Laboratory of Anesthesiology and Center for Pain Research and Treatment.; Department of Anesthesiology, Xuzhou Central Hospital, Jiangsu 221002, PR China Pharmacogn. Mag. A multifaceted peer reviewed journal in the field of Pharmacognosy and Natural Products. |
| Corresponding author | zhijian_fu@126.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 12, Issue 46s (2016) |
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