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Original ArticlePharmacognosy MagazineVol. 13 | Issue 51 | 2017 | pp. 345–350Open access
Anticancer Potential of Steviol in MCF-7 Human Breast Cancer Cells
- 1*,
- 2,
- 1,
- 2,
- 2,
- 1
- 1 Centre of Biotechnology, University of Allahabad, Allahabad, India.
- 2 Division of Biochemistry, Central Drug Research Institute, Lucknow, Uttar Pradesh, India.
Published in Pharmacognosy Magazine
Correspondence: Ena Gupta
Centre of Biotechnology, University of Allahabad, Allahabad, India.
Email: enaravish@gmail.com
Copyright: © 2017 Manuscript Technomedia. This is an open access article.
- Published:
- Jul 19, 2017
- Received:
- Jan 26, 2017
- DOI:
- 10.4103/pm.pm_29_17
How to cite
Gupta, E., Kaushik, S., Purwar, S., Sharma, R., Balapure, A. K., & Sundaram, S. (2017). Anticancer Potential of Steviol in MCF-7 Human Breast Cancer Cells. Pharmacognosy Magazine, 13(51), 345–350. https://doi.org/10.4103/pm.pm_29_17
Abstract
Objective: This study aimed to investigate the cytotoxicity, apoptosis induction, and mechanism of action of steviol on human breast cancer cells (Michigan Cancer Foundation‑7 [MCF‑7]). Materials and Methods: Sulforhodamine‑B assay was performed to analyze cytotoxic potential of Steviol whereas flow cytometer was used to analyze cell cycle, apoptosis, and reactive oxygen species generation. Results: Studying the viability of cells confirms the IC50 of Steviol in MCF‑7 cells which was 185 µM. The data obtained from fluorescence‑activated cell sorter analysis reveal Steviol‑mediated G2/M‑phase arrest (P < 0.05) in addition to the presence of evident sub‑G0/G1 peak (P < 0.05) in the MCF‑7 cells, signifying the ongoing apoptosis. Conclusion: Thus, results suggest that induction of apoptosis in MCF‑7 cells was due to dose‑dependent effect of Steviol. Our first in vitro findings indicate Steviol as a promising candidate for the treatment of breast cancer.
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Article metadata
| Title | Anticancer Potential of Steviol in MCF-7 Human Breast Cancer Cells |
|---|---|
| Authors | Ena Gupta; Shweta Kaushik; Shalini Purwar; Ramesh Sharma; Anil K. Balapure; Shanthy Sundaram |
| Affiliations | Centre of Biotechnology, University of Allahabad, Allahabad, India.; Division of Biochemistry, Central Drug Research Institute, Lucknow, Uttar Pradesh, India. |
| Corresponding author | enaravish@gmail.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 13, Issue 51 (2017) |
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