Hepatoprotective and Antioxidant Potential of Radish Seed Aqueous Extract on Cadmium‑induced Hepatotoxicity and Oxidative Stress in Mice

Objective: The research aimed to investigate the mitigation effect of RSE against Cd‑induced hepatotoxicity in experimental animals. Materials and Methods: The mice were administered intraperitoneally with Cd Chloride (CdCl2, 75 mg/kg b. wt) as a positive control to compare RSE. The hepatic function and antioxidant status were assessed in liver tissue of poisoned and control mice. Results: Levels of serum hepatic enzymes (aspartate transaminase: AST and alanine transaminase: ALT) as well as total bilirubin were significantly increased in Cd‑exposed mice. In addition, Cd exposure elicited enhancement of oxidative stress level. Co‑treatment with RSE (200 and 400 mg/kg b. wt) significantly decreased the serum levels of liver function biomarkers. Furthermore, RSE treatment showed a significant reduction of lipid peroxidation and increase of enzyme and glutathione concentrations. Histopathological analysis was parallel to these biochemical findings. Conclusion: The results clearly demonstrated that RSE is effective for ameliorating hepatic cytotoxicity and oxidative damage arising from Cd exposure.