Original ArticlePharmacognosy MagazineVol. 15 | Issue 61 | 2019 | pp. 277–282Open access
Antiproliferative and Antiangiogenic Effects of Zerumbone from Zingiber zerumbet L. Smith in Sprague Dawley Rat Model of Hepatocellular Carcinoma
- 2,3*,
- 3,
- 4,5,6,
- 7,
- 7,
- 8
- 1 Integrative Medicine Cluster, Sains@BERTAM, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Penang.
- 2 Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia.
- 3 Department of Clinic and Internal Medicine and, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.
- 4 Department of Medical Laboratory Sciences, College of Science, Komar University of Science and Technology, Sulaimani City, Iraq.
- 5 Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.
- 6 Departments of Microbiology and Pathology and, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.
- 7 Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
- 8 Anatomy and Pathology, College of Veterinary Medicine, University of Sulaimani.
Published in Pharmacognosy Magazine
Correspondence: Nozlena Abdul Samad
Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia.; Department of Clinic and Internal Medicine and, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.
Email: nozlena@usm.my
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 6, 2019
- Received:
- Mar 20, 2018
- DOI:
- 10.4103/pm.pm_118_18
How to cite
Samad, N. A., Abdul, A. B., Rahman, H. S., Abdullah, R., Ibrahim, T. A. T., & Othman, H. H. (2019). Antiproliferative and Antiangiogenic Effects of Zerumbone from Zingiber zerumbet L. Smith in Sprague Dawley Rat Model of Hepatocellular Carcinoma. Pharmacognosy Magazine, 15(61), 277–282. https://doi.org/10.4103/pm.pm_118_18
Abstract
Aims: This study aimed to investigate the in vivo antiproliferative and antiangiogenesis effects of ZER using rats with diethylnitrosamine‑induced hepatocellular carcinoma (HCC). Materials and Methods: The antiproliferative and anti‑angiogenesis effects of ZER were determined using the hepatosomatic index, vascular endothelial growth factor (VEGF) immunoassay, terminal deoxynucleotidyl transferase dUTP nick end labeling assay, histopathology, and immunohistochemistry analysis. Results: Nontreated rats with HCC had higher median liver weight than those treated with ZER or suramin. The expression of VEGF, matrix metalloprotease, and Ki‑67 that were high in nontreated HCC rats was down‑regulated with ZER or suramin treatments. Statistical Analysis Used: Statistical analyses were performed using the Statistical Package for Social Science version 21.0 (SPSS Inc, IBM, Maryland, USA). The data were expressed as the mean ± standard deviation and analyzed using a one‑way analysis of variance. P < 0.05 was considered statistically significant. Conclusion: ZER has the potential to be developed as the pro‑apoptotic and antiangiogenic agent in the treatment of HCC.
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Article metadata
| Title | Antiproliferative and Antiangiogenic Effects of Zerumbone from Zingiber zerumbet L. Smith in Sprague Dawley Rat Model of Hepatocellular Carcinoma |
|---|---|
| Authors | Nozlena Abdul Samad; Ahmad Bustamam Abdul; Heshu Sulaiman Rahman; Rasedee Abdullah; Tengku Azmi Tengku Ibrahim; Hemn Hassan Othman |
| Affiliations | Integrative Medicine Cluster, Sains@BERTAM, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Penang.; Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia.; Department of Clinic and Internal Medicine and, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.; Department of Medical Laboratory Sciences, College of Science, Komar University of Science and Technology, Sulaimani City, Iraq.; Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.; Departments of Microbiology and Pathology and, Institute, Universiti Sains Malaysia, Kepala Batas, Penang.; Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.; Anatomy and Pathology, College of Veterinary Medicine, University of Sulaimani. |
| Corresponding author | nozlena@usm.my |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 15, Issue 61 (2019) |
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