Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 15 | Issue 61 | 2019 | pp. 322–326Open access
Antinociceptive Activity of the Peptide Fraction from the Venom of Social Wasp Pseudopolybia vespiceps Testacea
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- 1 Department of Physiological Sciences, Neuropharmacology Laboratory, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
Published in Pharmacognosy Magazine
Correspondence: Marcia Renata Mortari
Department of Physiological Sciences, Neuropharmacology Laboratory, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
Email: mmortari@unb.br
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 6, 2019
- Received:
- May 11, 2018
- Accepted:
- Nov 12, 2018
- DOI:
- 10.4103/pm.pm_238_18
How to cite
Anjos, L. C. D., Gonçalves, J. C., Araujo, B. R. D., & Mortari, M. R. (2019). Antinociceptive Activity of the Peptide Fraction from the Venom of Social Wasp Pseudopolybia vespiceps Testacea. Pharmacognosy Magazine, 15(61), 322–326. https://doi.org/10.4103/pm.pm_238_18
Abstract
Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: The present study was aimed to evaluate the anti-inflammatory and antioxidant activities of <em>Crotalaria pallida</em> Aiton. Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model. The antioxidant activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, ferric reducing antioxidant power (FRAP) assay, and total phenolic content (TPC). Results: The methanolic extract of <em>C. pallida</em> showed significant anti-inflammatory activity in a dose-dependent manner. The extract also exhibited potent antioxidant activity with an IC50 value of 45.23 μg/mL in DPPH assay. The TPC was found to be 124.5 mg gallic acid equivalent/g of extract. Conclusion: The results suggest that <em>C. pallida</em> possesses significant anti-inflammatory and antioxidant properties, which could be attributed to the presence of phenolic compounds.
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Article metadata
| Title | Antinociceptive Activity of the Peptide Fraction from the Venom of Social Wasp Pseudopolybia vespiceps Testacea |
|---|---|
| Authors | Lilian Carneiro Dos Anjos; Jacqueline Coimbra Gonçalves; Bruna Ramos De Araujo; Marcia Renata Mortari |
| Affiliations | Department of Physiological Sciences, Neuropharmacology Laboratory, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. |
| Corresponding author | mmortari@unb.br |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 15, Issue 61 (2019) |
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