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Original ArticlePharmacognosy MagazineVol. 15 | Issue 62s | 2019 | pp. S150–S154Open access
Phytochemical Evaluation and Cytotoxic Potential of Chloroform Soluble Fraction of Methanol Extract of Thespesia populnea in Human Breast Cancer Cell Lines
- 1,
- 1*,
- 1,
- 1
- 1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Mannuthy, Thrissur, Kerala, India.
Published in Pharmacognosy Magazine
Correspondence: Bibu John Kariyil
Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Mannuthy, Thrissur, Kerala, India.
Email: bibujohn@kvasu.ac.in
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Apr 26, 2019
- Received:
- Jun 24, 2018
- DOI:
- 10.4103/pm.pm_329_18
How to cite
Gopalakrishnan, A., Kariyil, B. J., John, R., & Usha, P. T. A. (2019). Phytochemical Evaluation and Cytotoxic Potential of Chloroform Soluble Fraction of Methanol Extract of Thespesia populnea in Human Breast Cancer Cell Lines. Pharmacognosy Magazine, 15(62s), S150–S154. https://doi.org/10.4103/pm.pm_329_18
Abstract
Objective: The present study was undertaken to find out different phytochemical principles of chloroform- soluble fraction of T. populnea (CSFTP) using gas chromatography mass spectrometry-mass spectrometry (GCMS-MS) and Fourier-transform infrared (FTIR) spectroscopy and to analyze in vitro cytotoxic potential of the fraction in MDA-MB-231 and MCF-7 human breast carcinoma cell lines. Materials and Methods: Shade-dried bark of T. populnea was extracted using methanol and fractionated to obtain CSF. The fraction was subjected to GCMS, FTIR, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Results: GCMS-MS and FTIR analysis showed the presence of various steroids and fatty acid analogs. Cell growth inhibition was noted for CSFTP in MDA-MB-231 and MCF-7 cell lines. Conclusion: CSFTP revealed the presence of various active principles which could be attributed for its cytotoxic potential.
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Article metadata
| Title | Phytochemical Evaluation and Cytotoxic Potential of Chloroform Soluble Fraction of Methanol Extract of Thespesia populnea in Human Breast Cancer Cell Lines |
|---|---|
| Authors | Anu Gopalakrishnan; Bibu John Kariyil; Reni John; P. T. A. Usha |
| Affiliations | Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Mannuthy, Thrissur, Kerala, India. |
| Corresponding author | bibujohn@kvasu.ac.in |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 15, Issue 62s (2019) |
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