Morinda Citrifolia (Noni) Fruit Protects the Exocrine Pancreatic Dysfunction Against L‑Arginine Induced Acute Pancreatitis in Rats

Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: This study aimed to evaluate the antioxidant, anti-inflammatory, and cytotoxic activities of <em>Crotalaria pallida</em> Aiton. Materials and Methods: The antioxidant activity was assessed using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. Anti-inflammatory activity was evaluated by the inhibition of protein denaturation and membrane stabilization assays. Cytotoxicity was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against human breast cancer (MCF-7) cell lines. Results: The methanolic extract of <em>C. pallida</em> showed significant antioxidant activity with IC50 values of 42.5 ± 1.2 µg/mL for DPPH and 128.4 ± 3.5 µg/mL for FRAP. The extract also exhibited potent anti-inflammatory activity in a dose-dependent manner. Furthermore, the extract demonstrated significant cytotoxic activity against MCF-7 cells with an IC50 value of 68.2 ± 2.4 µg/mL. Conclusion: The results suggest that <em>C. pallida</em> possesses significant pharmacological potential, which could be attributed to the presence of bioactive phytochemicals.