Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 15 | Issue 64s | 2019 | pp. S320–S327Open access
Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol‑Induced Myocardial Oxidative Stress in Rats
- 1*,
- 2,
- 2,
- 1
- 1 Mamatha Madhugiri Gopinath, Ravikiran Tekupalli Department of Biotechnology, Jnanabharathi Campus, Bangalore University, India.
- 2 Ramaiah College of Arts Science and Commerce, Bengaluru, Karnataka, India.
Published in Pharmacognosy Magazine
Correspondence: Anupama Sindhaghatta Kariyappa
Mamatha Madhugiri Gopinath, Ravikiran Tekupalli Department of Biotechnology, Jnanabharathi Campus, Bangalore University, India.
Email: ravikiran@bub.ernet.in
Copyright: © 2019 Manuscript Technomedia. This is an open access article.
- Published:
- Aug 26, 2019
- Received:
- Dec 19, 2018
- DOI:
- 10.4103/pm.pm_642_18
How to cite
Kariyappa, A. S., Ramachandregowda, S., Anand, S., & Dundaiah, B. (2019). Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol‑Induced Myocardial Oxidative Stress in Rats. Pharmacognosy Magazine, 15(64s), S320–S327. https://doi.org/10.4103/pm.pm_642_18
Abstract
Objective: The present study was designed to evaluate the cardioprotective potential of Dh extract and its bioactive compounds on region‑specific responses against isoproterenol (ISO)‑induced myocardial injury in male Wistar rats. Materials and Methods: Rats were orally supplemented with ellagic acid (50 mg/kg body weight [BW]), 4‑hydroxy isophthalic acid (30 mg/kg BW), and Dh extract (100 mg/kg BW) for 30 days, and they were subsequently administered (intraperitoneally) with ISO (150 mg/kg BW) for the last 2 days. Results: ISO‑treated rats showed a significant increase in serum lipid profile, markers of cardiac damage, and decreased antioxidant status. Supplemented groups showed improved lipid profile, reduced serum marker enzymes, and enhanced antioxidant status in ISO‑administered rats. Histopathological studies further confirmed the protective effect of Dh extract against ISO‑induced myocardial infarction (MI). Conclusion: Our results demonstrated that Dh extract and its compounds efficiently ameliorated ISO‑induced MI in rats.
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Article metadata
| Title | Decalepis hamiltonii and its Bioactive Compounds Protects Isoproterenol‑Induced Myocardial Oxidative Stress in Rats |
|---|---|
| Authors | Anupama Sindhaghatta Kariyappa; Sowbhagya Ramachandregowda; Santosh Anand; Bhagyalakshmi Dundaiah |
| Affiliations | Mamatha Madhugiri Gopinath, Ravikiran Tekupalli Department of Biotechnology, Jnanabharathi Campus, Bangalore University, India.; Ramaiah College of Arts Science and Commerce, Bengaluru, Karnataka, India. |
| Corresponding author | ravikiran@bub.ernet.in |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 15, Issue 64s (2019) |
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