Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 16 | Issue 05s | 2020 | pp. S561–S565Open access
Effects of Artemisia judaica Essential Oil and Ethanolic Extract on Experimentally‑Induced Benign Prostatic Hyperplasia
- 1*,
- 2,
- 1,
- 1,
- 3,
- 1,
- 1,
- 4,
- 1,
- 1,
- 5,
- 6
- 1 Department of Biological Sciences, Faculty of Science, Yarmouk University.
- 2 SA, Northern Ireland, United Kingdom.
- 3 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University.
- 4 Department of Chemistry, Faculty of Science, Yarmouk University, Irbid.
- 5 Department of Biology, Jerash University, Jerash, Jordan.
- 6 School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, BT52.
Published in Pharmacognosy Magazine
Correspondence: Bahaa Al ‑Trad
Department of Biological Sciences, Faculty of Science, Yarmouk University.
Email: bahaa.tr@yu.edu.jo
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Nov 30, 2020
- Received:
- May 28, 2020
- Accepted:
- Aug 11, 2020
- DOI:
- 10.4103/pm.pm_216_20
How to cite
Al‑Trad, B., Zoubi, M. A., Migdady, M., Lahham, J., Aljabali, A. A., Shehab, M., Alomari, S., Al‑Qudah, M. A., Qar, J., Muhaidat, R., El‑Oqlah, A., & Tambuwala, M. M. (2020). Effects of Artemisia judaica Essential Oil and Ethanolic Extract on Experimentally‑Induced Benign Prostatic Hyperplasia. Pharmacognosy Magazine, 16(05s), S561–S565. https://doi.org/10.4103/pm.pm_216_20
Abstract
Objectives: The present study aimed to address the effects of EO and EE on experimentally‑induced BPH in rats. Materials and Methods: Four experimental groups were assigned with six rats in each group, including the corn oil vehicle as a control. The three other groups were induced to develop BPH by testosterone injection. The BPH rats were randomized into the BPH‑untreated group, BPH‑EO treated group (200 mg/kg/subcutaneously) and BPH‑EE treated group (500 mg/kg/orally). Results: The prostate weight/body ratio and epithelial thickness showed a significant reduction in the EO and EE treated groups compared to the BPH untreated. In addition, mRNA expression levels of the proliferating marker (proliferating cell nuclear antigen), the angiogenesis marker (vascular endothelial growth factor‑A) and interleukin‑6; an inflammatory cytokine, were significantly down‑regulated in the BPH groups that were treated with EE or EO. Conclusion: Our results indicated that in experimentally‑induced BPH, EO and EE from A. judaica ameliorate BPH development by inhibiting prostatic cell proliferation, angiogenesis, and inflammation.
Keywords
Subject
Article metadata
| Title | Effects of Artemisia judaica Essential Oil and Ethanolic Extract on Experimentally‑Induced Benign Prostatic Hyperplasia |
|---|---|
| Authors | Bahaa Al‑Trad; Mazhar Al Zoubi; Mu’ath Migdady; Jamil Lahham; Alaa AA Aljabali; Malek Shehab; Sahar Alomari; Mahmoud A Al‑Qudah; Janti Qar; Riyadh Muhaidat; Ahmad El‑Oqlah; Murtaza M. Tambuwala |
| Affiliations | Department of Biological Sciences, Faculty of Science, Yarmouk University.; SA, Northern Ireland, United Kingdom.; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University.; Department of Chemistry, Faculty of Science, Yarmouk University, Irbid.; Department of Biology, Jerash University, Jerash, Jordan.; School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, BT52. |
| Corresponding author | bahaa.tr@yu.edu.jo |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 05s (2020) |
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