Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 16 | Issue 69 | 2020 | pp. 250–257Open access
Protective Effect of Adropin against High Fat Diet‑induced Obese Diabetic Wistar Rats via Nuclear Factor Erythroid 2‑related Factor 2 Pathway
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- 1 Ya‑Jie Huo, Huan‑Huan Wang, Zhi‑Qiang Kang, Li He Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou City, Henan Province, China.
Published in Pharmacognosy Magazine
Correspondence: Fang Luo
Ya‑Jie Huo, Huan‑Huan Wang, Zhi‑Qiang Kang, Li He Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou City, Henan Province, China.
Email: helizhongxin@sina.cn
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 15, 2020
- Received:
- Sep 28, 2019
- Accepted:
- Feb 17, 2020
- DOI:
- 10.4103/pm.pm_434_19
How to cite
Luo, F., Li, Q., Zhang, F., Li, L., Song, L., Mao, Y., Li, J., Liu, H., Li, F., & Xu, L. (2020). Protective Effect of Adropin against High Fat Diet‑induced Obese Diabetic Wistar Rats via Nuclear Factor Erythroid 2‑related Factor 2 Pathway. Pharmacognosy Magazine, 16(69), 250–257. https://doi.org/10.4103/pm.pm_434_19
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em>. Materials and Methods: The methanolic extract of <em>C. arnottiana</em> leaves was evaluated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide, and hydroxyl radical scavenging assays. Anti-inflammatory activity was assessed using the carrageenan-induced rat paw edema model. Results: The extract showed significant antioxidant activity in a dose-dependent manner. In the anti-inflammatory assay, the extract at 200 and 400 mg/kg doses significantly reduced paw edema compared to the control group. Conclusion: <em>C. arnottiana</em> possesses significant antioxidant and anti-inflammatory properties, supporting its traditional use.
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Article metadata
| Title | Protective Effect of Adropin against High Fat Diet‑induced Obese Diabetic Wistar Rats via Nuclear Factor Erythroid 2‑related Factor 2 Pathway |
|---|---|
| Authors | Fang Luo; Qing‑Chu Li; Feng‑Jiao Zhang; Lei Li; Li‑Ge Song; Yu Mao; Jing Li; Hong‑Mei Liu; Feng‑Li Li; Ling‑Yu Xu |
| Affiliations | Ya‑Jie Huo, Huan‑Huan Wang, Zhi‑Qiang Kang, Li He Department of Endocrinology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou City, Henan Province, China. |
| Corresponding author | helizhongxin@sina.cn |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 69 (2020) |
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