Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 16 | Issue 69 | 2020 | pp. 400–408Open access
Clinacanthus nutans Aqueous Extract Suppresses the Release of Histamine and β‑Hexosaminidase in in-vitro Model of IgE‑Mediated Mast Cell Degranulation
- 2,
- 2,
- 3,
- 2,
- 4,5,6,
- 2,
- 3,7,
- 7,
- 2*
- 1 Department of Biomedical Science, Faculty of Medicine and Health Sciences.
- 2 Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, University, 56000 Kuala Lumpur, Malaysia.
- 3 Faculty of Pharmaceutical Sciences, UCSI University, 56000 Kuala Lumpur, Malaysia.
- 4 Graduate Institute of Brain and Mind Sciences, College of Medicine.
- 5 Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.
- 6 Laboratory of Natural Products, Institute of Bioscience.
- 7 Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, University, 56000 Kuala Lumpur, Malaysia.
Published in Pharmacognosy Magazine
Correspondence: Chau Ling Tham
Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, University, 56000 Kuala Lumpur, Malaysia.
Email: chauling@upm.edu.my
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 15, 2020
- Received:
- May 25, 2019
- Accepted:
- Nov 6, 2019
- DOI:
- 10.4103/pm.pm_221_19
How to cite
Kow, A. S. F., Fong, L. Y., Khoo, L. W., Tan, J. W., Lee, M. T., Israf, D. A., Abas, F., Shaari, K., & Tham, C. L. (2020). Clinacanthus nutans Aqueous Extract Suppresses the Release of Histamine and β‑Hexosaminidase in in-vitro Model of IgE‑Mediated Mast Cell Degranulation. Pharmacognosy Magazine, 16(69), 400–408. https://doi.org/10.4103/pm.pm_221_19
Abstract
Background: The genus <em>Crotalaria</em> (Fabaceae) is known for its diverse pharmacological activities. Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Crotalaria pallida</em> (MECP) whole plant. Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema and cotton pellet-induced granuloma models. The analgesic activity was assessed using acetic acid-induced writhing and tail-flick models in mice. Results: MECP (200 and 400 mg/kg) showed significant (P < 0.01) anti-inflammatory activity in both acute and chronic models. In the analgesic models, MECP exhibited significant (P < 0.01) reduction in the number of writhes and increased the reaction time in the tail-flick test. Conclusion: The results suggest that MECP possesses significant anti-inflammatory and analgesic activities, which may be attributed to the presence of phytochemicals like flavonoids and alkaloids.
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Article metadata
| Title | Clinacanthus nutans Aqueous Extract Suppresses the Release of Histamine and β‑Hexosaminidase in in-vitro Model of IgE‑Mediated Mast Cell Degranulation |
|---|---|
| Authors | Audrey Siew Foong Kow; Lai Yen Fong; Leng Wei Khoo; Ji Wei Tan; Ming-Tatt Lee; Daud Ahmad Israf; Faridah Abas; Khozirah Shaari; Chau Ling Tham |
| Affiliations | Department of Biomedical Science, Faculty of Medicine and Health Sciences.; Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, University, 56000 Kuala Lumpur, Malaysia.; Faculty of Pharmaceutical Sciences, UCSI University, 56000 Kuala Lumpur, Malaysia.; Graduate Institute of Brain and Mind Sciences, College of Medicine.; Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan.; Laboratory of Natural Products, Institute of Bioscience.; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 Serdang, University, 56000 Kuala Lumpur, Malaysia. |
| Corresponding author | chauling@upm.edu.my |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 69 (2020) |
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