Effect of Poly Herbal Formulation “Karisalai chooranam” against Detrimental Effects of Psychological Stress

Objectives: The objective is to evaluate the efficacy of KSC against detrimental effects of psychological stress. Materials and Methods: Male Wistar albino rats were subjected to restraint stress (6 h/day, 21 days). At the end of stress, rats were subjected to elevated plus maze (EPM) and Moris Water Maze studies. Blood was collected and examined for interleukin‑6 (IL‑6), IL‑10 by Enzyme‑Linked Immuno Sorbent Assay. Results: Restraint stress produced raise in the plasma IL‑6 and decrease in the IL‑10 level. Abnormalities in memory and anxiety level were seen. The effects of KSC in preventing detrimental effects on spatial recognition skill and reference memory were observed in Morris water maze analysis. In EPM trail, the anxiety developed due to restraint stress was prevented by the KSC. Conclusion: KSC was found to have action against psychological stress‑induced neurobehavioral changes and stress‑induced alteration in cytokines which play important roles in the development of psychological stress.