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Original ArticlePharmacognosy MagazineVol. 16 | Issue 70s | 2020 | pp. S435–S442Open access
Antitumoral Effect of Lawsonia inermis Extract on Melanoma Tumor‑bearing C57BL/6 Mice
- *,
- 1 Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, Madhya Pradesh, 2 Department of Central Laboratory Facility, Central Laboratory Facility, Chhattisgarh Council of Science and Technology, Raipur, Chhattisgarh, 3 Gujarat State Biotechnology Mission, Gandhinagar, Gujarat, India ORIGINAL ARTICLE.
Published in Pharmacognosy Magazine
Correspondence: Wasim Raja
Email: spdhanabal@jssuni.edu.in
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- May 20, 2020
- Received:
- May 21, 2019
- Accepted:
- Mar 12, 2020
- DOI:
- 10.4103/pm.pm_219_19
How to cite
Raja, W., & Pandey, S. (2020). Antitumoral Effect of Lawsonia inermis Extract on Melanoma Tumor‑bearing C57BL/6 Mice. Pharmacognosy Magazine, 16(70s), S435–S442. https://doi.org/10.4103/pm.pm_219_19
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em>. Materials and Methods: The antioxidant activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and total antioxidant capacity assays. The anti-inflammatory activity was evaluated using the protein denaturation inhibition assay and the membrane stabilization assay. Results: The methanolic extract of <em>C. arnottiana</em> showed significant antioxidant activity in all the assays. It also exhibited potent anti-inflammatory activity by inhibiting protein denaturation and stabilizing the red blood cell membrane. Conclusion: The results suggest that <em>C. arnottiana</em> has significant antioxidant and anti-inflammatory potential, which could be attributed to the presence of phytochemicals like flavonoids and phenolic compounds.
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Article metadata
| Title | Antitumoral Effect of Lawsonia inermis Extract on Melanoma Tumor‑bearing C57BL/6 Mice |
|---|---|
| Authors | Wasim Raja; Sonam Pandey |
| Affiliations | Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Bhopal, Madhya Pradesh, 2 Department of Central Laboratory Facility, Central Laboratory Facility, Chhattisgarh Council of Science and Technology, Raipur, Chhattisgarh, 3 Gujarat State Biotechnology Mission, Gandhinagar, Gujarat, India ORIGINAL ARTICLE. |
| Corresponding author | spdhanabal@jssuni.edu.in |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 70s (2020) |
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