Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 16 | Issue 71 | 2020 | pp. 531–537Open access
Chlorogenic Acid in Viscum album Callus is a Potential Anticancer Agent against C6 Glioma Cells
- 1*,
- 1*,
- 1*,
- 4,
- 5,
- 6,
- 7,
- 8*
- 1 Department of Gyeongsangbuk-do Arboretum, Sumogwon-ro 647, Pohang, Gyeongbuk (37502).
- 2 Research and Development Center, UMUST R&D Corporation, Neungdong-ro, Gwangjin-gu, Seoul (05029).
- 3 Department of Nuclear Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul (07804).
- 4 National Marine Biodiversity Institute of Korea, Jangsan-ro, Seocheon, Chungcheongnam-do (33662), Republic of Korea.
- 5 Korea Basic Science Institute, Seoul, (02841).
- 6 Department of Bio-Science, College of Natural Science, Dongguk University, Dongdae-ro, Gyeongju, Gyeongbuk (38066).
- 7 Physical Activity & Performance Institute, Konkuk University, Neungdong-ro, Gwangjin-gu, Seoul (05029).
- 8 Department of Sports Medicine and Science in Graduated School, Konkuk University, Neungdong-ro, Gwangjin-gu, Seoul (05029), Republic of Korea.
Published in Pharmacognosy Magazine
Correspondence: Jinwoo Kim
Department of Gyeongsangbuk-do Arboretum, Sumogwon-ro 647, Pohang, Gyeongbuk (37502).
Email: kimpro@konkuk.ac.kr
Correspondence: Suji Baek
Department of Gyeongsangbuk-do Arboretum, Sumogwon-ro 647, Pohang, Gyeongbuk (37502).
Email: kimpro@konkuk.ac.kr
Correspondence: Kang Pa Lee
Department of Gyeongsangbuk-do Arboretum, Sumogwon-ro 647, Pohang, Gyeongbuk (37502).
Email: kimpro@konkuk.ac.kr
Correspondence: Jisu Kim
Department of Sports Medicine and Science in Graduated School, Konkuk University, Neungdong-ro, Gwangjin-gu, Seoul (05029), Republic of Korea.
Email: kimpro@konkuk.ac.kr
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Oct 20, 2020
- Received:
- Nov 9, 2019
- Accepted:
- Mar 17, 2020
- DOI:
- 10.4103/pm.pm_479_19
How to cite
Kim, J., Baek, S., Lee, K. P., Moon, B. S., Kim, H. S., Kwon, S. H., Lee, D. W., & Kim, J. (2020). Chlorogenic Acid in Viscum album Callus is a Potential Anticancer Agent against C6 Glioma Cells. Pharmacognosy Magazine, 16(71), 531–537. https://doi.org/10.4103/pm.pm_479_19
Abstract
Objective: Our study aimed to explore the anticancer effects of CA obtained from Viscum album callus on C6 glioma cell migration and proliferation. Materials and Methods: Anticancer potency was analyzed by the 2,3‑bis‑(2‑methoxy‑4‑nitro‑5‑sulfophenyl)‑2H‑tetrazolium‑5‑carboxanilide salt assay to assess the ability to inhibit cell growth and proliferation. Cell mobility was investigated based on the Boyden chamber and the scratch wound healing assay. Factors involved in cell cycle progression were evaluated by mRNA and protein expression. Cell death was determined by staining with specific dyes and fluorescence microscopy. Results: CA significantly reduced C6 glioma cell proliferation and migration. Furthermore, it induced reactive oxygen species generation and apoptotic cell death. Treatment with CA also suppressed extracellular signal‑regulated kinase ½ (ERK½) phosphorylation and the gene expression of cyclins E and A. Conclusion: Our results show that CA may regulate glioma cell migration and proliferation via modulation of ERK½ phosphorylation and cell cycle regulation. Thus, it might be a potent anticancer agent in preventing progression of glioma.
Keywords
Subject
Article metadata
| Title | Chlorogenic Acid in Viscum album Callus is a Potential Anticancer Agent against C6 Glioma Cells |
|---|---|
| Authors | Jinwoo Kim; Suji Baek; Kang Pa Lee; Byung Seok Moon; Hyun-Soo Kim; Seung-Hae Kwon; Dae won Lee; Jisu Kim |
| Affiliations | Department of Gyeongsangbuk-do Arboretum, Sumogwon-ro 647, Pohang, Gyeongbuk (37502).; Research and Development Center, UMUST R&D Corporation, Neungdong-ro, Gwangjin-gu, Seoul (05029).; Department of Nuclear Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul (07804).; National Marine Biodiversity Institute of Korea, Jangsan-ro, Seocheon, Chungcheongnam-do (33662), Republic of Korea.; Korea Basic Science Institute, Seoul, (02841).; Department of Bio-Science, College of Natural Science, Dongguk University, Dongdae-ro, Gyeongju, Gyeongbuk (38066).; Physical Activity & Performance Institute, Konkuk University, Neungdong-ro, Gwangjin-gu, Seoul (05029).; Department of Sports Medicine and Science in Graduated School, Konkuk University, Neungdong-ro, Gwangjin-gu, Seoul (05029), Republic of Korea. |
| Corresponding author | kimpro@konkuk.ac.kr |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 71 (2020) |
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