Open access · Peer reviewed · No APCs
Research ArticlePharmacognosy MagazineVol. 2 | Issue 5 | 2006 | pp. 42–43Open access
Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci and tumors in the rat colon by resveratrol
- 1,
- 1*
- 1 Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India.
Published in Pharmacognosy Magazine
Correspondence: Nalini N
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India.
Email: nalininam@yahoo.com
Copyright: © 2006 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2006
How to cite
M, S., & N, N. (2006). Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci and tumors in the rat colon by resveratrol. Pharmacognosy Magazine, 2(5), 42–43.
Abstract
The purpose of the present study was to investigate the effect of resveratrol (RES) on 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. The numbers of colon tumors and the formation of aberrant crypt foci (ACF), a premalignant lesion in rats were significantly reduced on resveratrol (8 mg/kg body weight) supplementation. Moreover, resveratrol supplementation for the entire treatment period showed significantly better chemopreventive activity against DMH-induced rat colon carcinogenesis as compared to resveratrol supplementation during the initiation and post-initiation stages of carcinogenesis.
Keywords
Subject
Article metadata
| Title | Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci and tumors in the rat colon by resveratrol |
|---|---|
| Authors | Sengottuvelan M; Nalini N |
| Affiliations | Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India. |
| Corresponding author | nalininam@yahoo.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 2, Issue 5 (2006) |
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