Pharmacological effects of Trigonella foenum graecum Linn. seeds on various isolated perfused smooth muscle preparations

In the present study, the pharmacological effects on different smooth muscles by the extracts like total alcoholic (TA), total aqueous (TQ), petroleum ether (PE), total alkaloidal (TK), total glycosidal (TG) and a phytochemical trigonelline (TR) from Trigonella foenum graecum Linn. seeds was investigated using isolated organ bath preparation method. 1 mg/ml dose of the extracts and the phytochemical showed significant anti-histaminic activity on guinea pig ileum, anti-cholinergic effect on rat colon and uterine stimulant activity on rat uterus. These results might be due the presence of some spasmolytic and spasmogenic constituents in the Trigonella foenum graecum Linn. (Fenugreek) seeds. These findings will help to invent some novel therapeutics from the fenugreek seeds.