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Research ArticlePharmacognosy MagazineVol. 3 | Issue 11 | 2007 | pp. 167–168Open access
Evaluation of the antitumor and trypanocidal activities and alkaloid profile in species of Brazilian Cactaceae
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- 1 Departamento de Química Orgânica, Instituto de Química, Centro de Tecnologia, Bloco A, Universidade Federal do Rio de Janeiro, 21941-909, Rio de Janeiro, RJ, Brazil.
- 2 Jardín Botánico, Instituto de Biologia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Deleg. Coyoacán, CP 04510, DF, México.
- 3 Instituto de Tecnologia em Fármacos, Fundação Oswaldo Cruz, R. Sizenando Nabuco 100, 21041-250, Rio de Janeiro, RJ, Brazil.
Published in Pharmacognosy Magazine
Correspondence: Ligia M. M. Valente
Departamento de Química Orgânica, Instituto de Química, Centro de Tecnologia, Bloco A, Universidade Federal do Rio de Janeiro, 21941-909, Rio de Janeiro, RJ, Brazil.
Email: valente@iq.ufrj.br
Copyright: © 2007 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2007
How to cite
Valente, L. M. M., Scheinvar, L. A., Silva, G. C., Antunes, A. P., Santos, F. A. L., Oliveira, T. F., Tappin, M. R. R., Neto, F. R., Pereira, A. S., Carvalhaes, S. F., Siani, A. C., Santos, R. R., Soares, R. O. A., Ferreira, E. F., Bozza, M., Stutz, C., & Gibaldi, D. (2007). Evaluation of the antitumor and trypanocidal activities and alkaloid profile in species of Brazilian Cactaceae. Pharmacognosy Magazine, 3(11), 167–168.
Abstract
Brazilian species of five genus of the family Cactaceae were screened for in vitro antitumor activity in a mechanism-based yeast bioassay using DNA repair- or recombination-deficient mutants of the yeast Saccharomyces cerevisiae, and in an assay using six different tumor cells. Whereas some species showed to be selectively active against some tumor cells, all of them were inactive in the S. cerevisiae assay, thus, demonstrating that the antitumor activity is not related either to the DNA damaging and/or to the topoisomerase I and II inhibition mechanisms. An evaluation for trypanocidal activity in trypomastigote forms of Trypanosoma cruzi showed that three species were especially active. The determination of the alkaloid profile of four species through TLC, HT-HRGC, HT-HRGC-MS and HPLC-PAD revealed, in all the species, low concentrations of alkaloids in complex mixtures with no major compounds.
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Article metadata
| Title | Evaluation of the antitumor and trypanocidal activities and alkaloid profile in species of Brazilian Cactaceae |
|---|---|
| Authors | Ligia M. M. Valente; Leia A. Scheinvar; Gilson C. Silva; Ana P. Antunes; Flávia A. L. Santos; Tatiana F. Oliveira; Marcelo R. R. Tappin; Francisco R. Neto; Alberto S. Pereira; Sergio F. Carvalhaes; Antonio C. Siani; Ricardo R. Santos; Renata O. A. Soares; Edmir F. Ferreira; Marcelo Bozza; Claudia Stutz; Daniel Gibaldi |
| Affiliations | Departamento de Química Orgânica, Instituto de Química, Centro de Tecnologia, Bloco A, Universidade Federal do Rio de Janeiro, 21941-909, Rio de Janeiro, RJ, Brazil.; Jardín Botánico, Instituto de Biologia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Deleg. Coyoacán, CP 04510, DF, México.; Instituto de Tecnologia em Fármacos, Fundação Oswaldo Cruz, R. Sizenando Nabuco 100, 21041-250, Rio de Janeiro, RJ, Brazil. |
| Corresponding author | valente@iq.ufrj.br |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 3, Issue 11 (2007) |
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