Open access · Peer reviewed · No APCs
Research ArticlePharmacognosy MagazineVol. 3 | Issue 11 | 2007 | pp. 163–164Open access
Antimycobacterial, antiviral and cytotoxic studies of Indigofera aspalathoides Vahl
- 1*,
- 2,
- 4,
- 3,
- 1,
- 1,
- 1,
- 3,
- 5,
- 6
- 1 Department of Pharmacology, Vel’s College of Pharmacy, Velan Nagar, Pallavaram, Chennai – 600 117, India.
- 2 Institute of Pharmacology, Madurai Medical College, Madurai – 625 020, India.
- 3 Cancer and Aging Research Lab, University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009, India.
- 4 Pharmacy Division, Mother Theresa Institute of Health Science, Pondicherry – 605 006, India.
- 5 Rega Institute, Katholieke Universiteit Luven, Minderbroadersstrat, B-3000 Luven, Belgium.
- 6 Institute for Tuberculosis Research, College of Pharmacy, University of Illinois, Chicago, Illinois 60612-723, USA.
Published in Pharmacognosy Magazine
Correspondence: B. Rajkapoor
Department of Pharmacology, Vel’s College of Pharmacy, Velan Nagar, Pallavaram, Chennai – 600 117, India.
Email: rajkapoorb@yahoo.co.in
Copyright: © 2007 Manuscript Technomedia. This is an open access article.
- Published:
- Jan 1, 2007
How to cite
Rajkapoor, B., Murugesh, N., Kavimani, S., Krishna, D., Ravichandran, V., Gobinath, M., Harikrishnan, N., Vidyasagar, J., Clercq, E. D., & Franzblau, S. G. (2007). Antimycobacterial, antiviral and cytotoxic studies of Indigofera aspalathoides Vahl. Pharmacognosy Magazine, 3(11), 163–164.
Abstract
Alcohol extract of Indigofera aspalathoides was tested for antimycobacterial activity against Mycobacterium tuberculosis (H37Rv), antiviral activity against HEL Cell culture (herpes simplex virus-1 KOS, herpes simplex virus-2 G, vaccinia virus, vesicular stomatitis virus and herpes simplex virus-TK KOS ACV), HeLa cell culture (vesicular stomatitis virus, coxsackie virus B4 and respiratory syncytial virus) and cytotoxic activity against human epithelial larynx cancer cells (HEp2), human breast cancer (HBL-100) and cervical carcinoma cells (HeLa) cell lines. The results showed that the extract produced 48% inhibition for antimycobacterial and >80 µg/ml of minimum inhibitory concentration against HEL and HeLa cell cultures of antiviral studies. In cytotoxic studies IC50 value of extract were found 117, >300 and 210 µg/ml against HEp2, HBL-100 and HeLa cells respectively. These studies clearly indicate that extract exhibited antimycobacterial, antiviral and cytotoxic activity.
Keywords
Subject
Article metadata
| Title | Antimycobacterial, antiviral and cytotoxic studies of Indigofera aspalathoides Vahl |
|---|---|
| Authors | B. Rajkapoor; N. Murugesh; S. Kavimani; D.R. Krishna; V. Ravichandran; M. Gobinath; N. Harikrishnan; J. Vidyasagar; E. De Clercq; Scott G. Franzblau |
| Affiliations | Department of Pharmacology, Vel’s College of Pharmacy, Velan Nagar, Pallavaram, Chennai – 600 117, India.; Institute of Pharmacology, Madurai Medical College, Madurai – 625 020, India.; Cancer and Aging Research Lab, University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009, India.; Pharmacy Division, Mother Theresa Institute of Health Science, Pondicherry – 605 006, India.; Rega Institute, Katholieke Universiteit Luven, Minderbroadersstrat, B-3000 Luven, Belgium.; Institute for Tuberculosis Research, College of Pharmacy, University of Illinois, Chicago, Illinois 60612-723, USA. |
| Corresponding author | rajkapoorb@yahoo.co.in |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 3, Issue 11 (2007) |
Also in this issue
- Optimization of curcumin extraction by microwave assisted in vitro plant cell bursting by orthogonal array designed extraction process and HPTLC analysispp. 132–133
- Determination of topical anti-inflammatory activity of the essential oil and extracts of Lippia alba (Mill.) N.E. Brown (Verbenaceae), using the model of mouse ear edema induced by TPA and AApp. 139–140
- Antinociceptive activity and toxicological study of aqueous leaf extract of Justicia gendarussa Burm. F. in ratspp. 145–146
- Phytochemical studies on roots of Gmelina asiatica Linn.pp. 156–158
- ardioactive effects from freshwater algae Oscillatoria limnetica, Hydrodictyon reticulatum, and Microcoleous lacustrispp. 159–160
Readers Also Viewed
Development and Validation of UV/visible Spectrophotometric Method for Estimation of Piroxicam from Bulk and Formulation
Sandip Mohan Honmane, Kunal Rajaram Yadav, Yuvraj Dilip Dange
Apr 23, 2025
Effects of Artificial Intelligence on Academic Performance of Library and Information Science University Students: A Meta-Analysis (2023-2025)
Kayode Sunday John Dada
Aug 6, 2026
Bridging Innovation and Impact: A Multidisciplinary Approach to Contemporary Research Challenges
Mueen Ahmed KK
Aug 11, 2026