Antihyperlipidemic activity of Camellia sinensis leaves in Triton WR-1339 induced albino rats

Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. Literature claims that flavonoids are able to reduce hyperlipidemia. Based on high flavonoid content in herbal plants, Camellia sinensis (CS) was selected and the present study focus on the anti-hyperlipidemic activity of aqueous extract of leaves of CS against Triton induced hyperlipidemia in rats. CS was administered at a dose of 200µg/kg (p.o) to Triton induced hyperlipidemic rats. Fenofibrate was used as reference standard. CS shows a significant decrease in the levels of serum cholesterol, phospholipid, triglyceride, LDL, VLDL and significant increase in the level of serum HDL at the dose of 200µg/kg (p.o) against Triton induced hyperlipidemic in rats. Aqueous extract of leaves of CS was investigated for its hypolipidemic activity on Triton induced hyperlipidemic profile. Aqueous extract fraction decreased serum level of total cholesterol by 69.72%. On the other hand aqueous extract of CS increased the serum HDL cholesterol level by 24.11%. The reduction of LDL cholesterol level by aqueous extract was 30.31%.