Biological activity of Coumarins from Launaea resedifolia

Four coumarin compounds were isolated from the methylene chloride-methanol (1:1) extract of the aerial parts of Launaea resedifolia, namely, Resedin A (I), Resedin B (II), Resedin C (III) and Resedin D (IV). The structures were elucidated by 1D, 2D-NMR and HR-CIMS analysis. Biological activity of isolated compounds were carried out. These compounds showed high antibacterial activity against some Gram–positive bacteria as Bacillus cereus and Staphyllococcus aureus in minimum inhibitory concentrations of 200 and 400 µg/mL. However, they showed no effect on tested Gram–negative bacteria as Serratia Sp., Pseudomonas Sp and Escherichia coli).