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Original ArticlePharmacognosy MagazineVol. 8 | Issue 32 | 2012 | pp. 245–249Open access
Zinc administration modulates radiation-induced oxidative injury in lens of rat
- 1*,
- 2,
- 3,
- 4,
- 5,
- 1,
- 1,
- 1,
- 6
- 1 Departments of Medical Biochemistry, University, Medical School, Gaziantep, Turkey.
- 2 Ophthalmology and, Turkey.
- 3 Department of Chemistry, Science and Art Faculty, Kilis 7 Aralık University, Kilis, Turkey.
- 4 Department of Biochemistry, Ataturk University, School of Medicine, Erzurum, Turkey.
- 5 Department of Ophthalmology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
- 6 Radiation Oncology, Gaziantep University, Medical School, Gaziantep, Turkey.
Published in Pharmacognosy Magazine
Correspondence: Seyithan Taysi
Departments of Medical Biochemistry, University, Medical School, Gaziantep, Turkey.
Copyright: © 2012 Manuscript Technomedia. This is an open access article.
- Published:
- Nov 22, 2012
- Received:
- Nov 30, 2011
How to cite
Taysi, S., Okumus, S., Akyuz, M., Uzun, N., Aksoy, A., Demir, E., Orkmez, M., Tarakcioglu, M., & Adli, M. (2012). Zinc administration modulates radiation-induced oxidative injury in lens of rat. Pharmacognosy Magazine, 8(32), 245–249. https://doi.org/10.4103/0973-1296.103646
Abstract
Background: The aim of this study was to evaluate the antioxidant role of zinc (Zn) against radiation-induced cataract in the rat lens after total cranial irradiation with a single 5 Gray (Gy) dose of gamma irradiation. Materials and Methods: Twenty-one Sprague-Dawley rats were used for the experiment. The control group did not receive Zn or irradiation but received 1-ml saline orally plus sham-irradiation. The irradiation (IR) group received 5 Gy gamma irradiation to the total cranium as a single dose plus 0.1 ml physiological saline intraperitoneally. The IR plus Zn group received irradiation to total cranium plus 10 mg/kg/day Zn intraperitoneally. Biochemical parameters measured in rat lenses were carried out using spectrophotometric techniques. Results: Lens total (enzymatic plus non-enzymatic) superoxide scavenger activity (TSSA), glutathione reductase (GRD), and glutathione-S-transferase (GST) activities significantly increased in the IR plus Zn groups when compared with the IR group. However, TSSA, GRD and GST activities were significantly lower in the IR group when compared with the control group. Lens non-enzymatic superoxide scavenger activity (NSSA) in the IR plus Zn group was significantly increased compared to that of the IR group. Lens xanthine oxidase (XO) activity in the IR group significantly increased compared to that of both the control and IR plus Zn groups. Conclusion: Zn has clear antioxidant properties and prevented oxidative stress by scavenging free radicals generated by ionizing radiation in rat lenses.
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Article metadata
| Title | Zinc administration modulates radiation-induced oxidative injury in lens of rat |
|---|---|
| Authors | Seyithan Taysi; Seydi Okumus; Mehmet Akyuz; Naim Uzun; Adnan Aksoy; Elif Demir; Mustafa Orkmez; Mehmet Tarakcioglu; Mustafa Adli |
| Affiliations | Departments of Medical Biochemistry, University, Medical School, Gaziantep, Turkey.; Ophthalmology and, Turkey.; Department of Chemistry, Science and Art Faculty, Kilis 7 Aralık University, Kilis, Turkey.; Department of Biochemistry, Ataturk University, School of Medicine, Erzurum, Turkey.; Department of Ophthalmology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.; Radiation Oncology, Gaziantep University, Medical School, Gaziantep, Turkey. |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 8, Issue 32 (2012) |
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