Open access · Peer reviewed · No APCs
Original ArticlePharmacognosy MagazineVol. 9 | Issue 35 | 2013 | pp. 196–201Open access
Interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42)
- 1*,
- 2,
- 1,
- 1
- 1 College of Pharmacy, South-Central University for Nationalities, Minyuan Road 708, Hongshan District, Wuhan, Hubei, 430074, China.
- 2 Center of Analysis, Guangdong Medical College, Dongguan, 523808, P. R, China.
Published in Pharmacognosy Magazine
Correspondence: Li Shuai
College of Pharmacy, South-Central University for Nationalities, Minyuan Road 708, Hongshan District, Wuhan, Hubei, 430074, China.
Email: shuaich@163.com
Copyright: © 2013 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 11, 2013
- Received:
- Jun 20, 2012
How to cite
Shuai, L., Chen, Z., Gao, R., & Yang, T. (2013). Interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42). Pharmacognosy Magazine, 9(35), 196–201. https://doi.org/10.4103/0973-1296.113262
Abstract
Background: Lobed kudzuvine root and rhizoma chuanxiong are effective drugs in traditional Chinese medicine. Objective: Extracts of the two medicines were investigated for their in vitro of beta-amyloid (Aβ1-42)-aggregation-and acetylcholinesterase (AChE)-inhibitory activities. Materials and Methods: The interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42) were studied by Michaelis–Menten equations, Thioflavin T (ThT) fluorescence analysis and transmission electron microscope (TEM). Results: Inhibition of acetylcholinesterase showed that 1-butanol fraction of the two medicines were noncompetitive inhibition, apparent inhibition constants were 9.947 and 7.1523. ThT fluorescence analysis and TEM results indicated that inhibition of the water fraction and 1-butanol fraction (both lobed kudzuvine root and rhizoma chuanxiong) was better. Conclusion: The result supported further research on chemical constituents and pharmacological mechanisms.
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Article metadata
| Title | Interaction of lobed kudzuvine root, rhizoma chuanxiong with both acetylcholinesterase and beta-amyloid (Aβ1-42) |
|---|---|
| Authors | Li Shuai; Zhi Chen; Ruixi Gao; Tianming Yang |
| Affiliations | College of Pharmacy, South-Central University for Nationalities, Minyuan Road 708, Hongshan District, Wuhan, Hubei, 430074, China.; Center of Analysis, Guangdong Medical College, Dongguan, 523808, P. R, China. |
| Corresponding author | shuaich@163.com |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 9, Issue 35 (2013) |
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