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Original ArticleIndian Journal of Pharmaceutical Education and ResearchVol. 58 | Issue 1 | 2023 | pp. 175–184Open access
Spectral Characterization, Antioxidant and Antibacterial Activities of Cold Methanolic Extract of Sweet Basil (Ocimum basilicum L.) Leaves Growing in Jazan, Kingdom of Saudi Arabia
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- 1 Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
- 2 Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, SAUDI ARABIA
- 3 Health Research Center, Jazan University, Jazan, SAUDI ARABIA
- 4 Unit of Medical Microbiology, College of Applied Medical Sciences, Jazan University, Jazan, SAUDI ARABIA
- 5 Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
- 6 Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
- 7 Department of Pharmacology, Dr. Joseph Mar Thoma Institute of Pharmaceutical Sciences and Research, Kattanam, Alappuzha, Kerala, INDIA
Published in Indian Journal of Pharmaceutical Education and Research
Correspondence: Md Shamsher Alam
Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
Email: mosalam@jazanu.edu.sa
Correspondence: Waquar Ahsan
Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
Email: wmohammad@jazanu.edu.sa
Copyright: © 2023 Manuscript Technomedia. This is an open access article.
- Published:
- Dec 20, 2023
- Received:
- Aug 28, 2024
- Accepted:
- Oct 4, 2024
How to cite
Alam, M. S., Albratty, M., Ahmed, H. A. H., Najmi, A., Zoghebi, K., Rehman, Z. U., Basode, V. K., Moni, S. S., Alam, M. F., Ahsan, W., & Kochikuzhyil, B. M. (2023). Spectral Characterization, Antioxidant and Antibacterial Activities of Cold Methanolic Extract of Sweet Basil (Ocimum basilicum L.) Leaves Growing in Jazan, Kingdom of Saudi Arabia. Indian Journal of Pharmaceutical Education and Research, 58(1), 175–184. https://doi.org/10.5530/ijper.20250719
Abstract
Background
This study evaluated the chemical composition, antioxidant activity and antibacterial properties of methanol extracts of Ocimum basilicum L. leaves that were gathered from the Kingdom of Saudi Arabia’s Jazan province.
Materials and Methods
The extract was examined using FTIR and GC-MS techniques, which revealed the presence of terpenes (53.14%), Linalool (24.5%), sulfoxides (4.19%), cinnamic acid (5.23%), fatty acid esters (1.45%) and phthalic acid esters (0.72%).
Results
The extract contained significant levels of total phenolic compounds and demonstrated a DPPH radical scavenging capacity of 33.70%, which is considered to be good. The antibacterial activity spectrum of O. basilicum leaves’ methanolic extract was found to be broader. The extract was tested against eight different bacteria strains, including S. cholestasis, S. aureus, S. epidermidis, K. pneumoniae, E. coli, P. mirabilis, E. faecalis, and S. cholestasis.
Conclusion
With an inhibition zone of 21 mm, S. aureus exhibited the highest level of antibacterial activity, whereas P. aeruginosa demonstrated the lowest value, with an inhibition zone of 15 mm. Nonetheless, the activity range was more constrained than that of regular ciprofloxacin discs.
Keywords
Subject
Article metadata
| Title | Spectral Characterization, Antioxidant and Antibacterial Activities of Cold Methanolic Extract of Sweet Basil (Ocimum basilicum L.) Leaves Growing in Jazan, Kingdom of Saudi Arabia |
|---|---|
| Authors | Md Shamsher Alam; Mohammed Albratty; Hassan Ahmed Hassan Ahmed; Asim Najmi; Khalid Zoghebi; Zia ur Rehman; Vinod Kumar Basode; Sivakumar S. Moni; Mohammad Firoz Alam; Waquar Ahsan; Benson Mathai Kochikuzhyil |
| Affiliations | Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA; Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, SAUDI ARABIA; Health Research Center, Jazan University, Jazan, SAUDI ARABIA; Unit of Medical Microbiology, College of Applied Medical Sciences, Jazan University, Jazan, SAUDI ARABIA; Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA; Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA; Department of Pharmacology, Dr. Joseph Mar Thoma Institute of Pharmaceutical Sciences and Research, Kattanam, Alappuzha, Kerala, INDIA |
| Corresponding author | mosalam@jazanu.edu.sa |
| Journal | Indian Journal of Pharmaceutical Education and Research |
| Volume / Issue | Vol. 58, Issue 1 (2023) |
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