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Original ArticlePharmacognosy MagazineVol. 16 | Issue 69 | 2020 | pp. 347–352Open access
Study on the Characteristics of Pharmacokinetics of Different Doses of Gastrodin in Mice
- 1,
- 1,
- 1*,
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- 1 College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, China.
Published in Pharmacognosy Magazine
Correspondence: Xing Wang
College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, China.
Email: wshing@swjtu.edu.cn
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 15, 2020
- Received:
- Jul 21, 2019
- Accepted:
- Feb 17, 2020
- DOI:
- 10.4103/pm.pm_307_19
How to cite
Wang, X., Liu, X., Wang, X., & Dong, Y. (2020). Study on the Characteristics of Pharmacokinetics of Different Doses of Gastrodin in Mice. Pharmacognosy Magazine, 16(69), 347–352. https://doi.org/10.4103/pm.pm_307_19
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant used in traditional medicine for bone healing. Objective: The present study was aimed to evaluate the anti-inflammatory and analgesic activities of the methanolic extract of <em>Cissus quadrangularis</em> (MECQ) in experimental animal models. Materials and Methods: The anti-inflammatory activity was evaluated using carrageenan-induced rat paw edema model, and analgesic activity was assessed using acetic acid-induced writhing and hot plate methods in mice. Results: MECQ at doses of 200 and 400 mg/kg showed significant (P < 0.01) anti-inflammatory activity in carrageenan-induced rat paw edema. In analgesic models, MECQ exhibited significant (P < 0.01) reduction in the number of writhes in acetic acid-induced writhing test and increased the reaction time in hot plate method. Conclusion: The results suggest that MECQ possesses significant anti-inflammatory and analgesic activities, which supports its traditional use.
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Article metadata
| Title | Study on the Characteristics of Pharmacokinetics of Different Doses of Gastrodin in Mice |
|---|---|
| Authors | Xinyu Wang; Xin Liu; Xing Wang; Yu Dong |
| Affiliations | College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, China. |
| Corresponding author | wshing@swjtu.edu.cn |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 69 (2020) |
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