Antioxidant and anti-inflammatory activities of Cissus arnottiana B. Heyne ex Planch

Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is a well-known medicinal plant, but other species are less explored. Objective: To evaluate the antioxidant and anti-inflammatory activities of <em>Cissus arnottiana</em> B. Heyne ex Planch. Materials and Methods: The methanolic extract of <em>C. arnottiana</em> leaves was evaluated for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide, and hydroxyl radical scavenging assays. Anti-inflammatory activity was assessed using the protein denaturation inhibition assay and the carrageenan-induced rat paw edema model. Results: The extract showed significant antioxidant activity in a concentration-dependent manner. In the anti-inflammatory assay, the extract exhibited significant inhibition of protein denaturation and reduced paw edema in rats compared to the standard drug, diclofenac sodium. Conclusion: <em>C. arnottiana</em> possesses significant antioxidant and anti-inflammatory activities, supporting its traditional use.