Quercetin of Potentilla bifurca 3‑Glycosylation Substitution Impact the Inhibitory Activity on α‑glucosidase

Background: Inhibition of glycosidase activity is an effective diabetes therapy and prevention strategy. In this study, we aimed to explore the effects of quercetin and its derivatives extracted from Potentilla bifurca on α‑glycosidaseinhibited vitality. Materials and Methods: Various chromatographic methods and separation techniques were used to separate quercetin and quercetin derivatives. An enzyme reaction system was established to determine the inhibitory activity of P. bifurca compounds against α‑glucosidase and the type of enzyme inhibitor reaction. Results: The changes in activity between quercetin and its derivatives is observed in the following areas: (1) The action of flavonoids is expected to be influenced by the substituents of different molecules. Glycosylation of quercetin reduces its hypoglycemic effect, and the molecule created after adding penta‑glycoside is larger than that formed after adding hexa‑glycoside. (2) The acylated drugs can possibly reduce their activity. Conclusion: P. bifurca has been shown to inhibit glycosidase activity, making it effective in diabetes treatment.