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Original ArticlePharmacognosy MagazineVol. 12 | Issue 46 | 2016 | pp. 98–103Open access
Quality Analysis of Chlorogenic Acid and Hyperoside in Crataegi fructus
- 2,
- 2,
- 2*
- 1 Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University.
- 2 Department of Biomaterials Engineering, Kangwon National University, Chuncheon 200‑701, Korea.
Published in Pharmacognosy Magazine
Correspondence: Choong Je Ma
Department of Biomaterials Engineering, Kangwon National University, Chuncheon 200‑701, Korea.
Email: cjma@kangwon.ac.kr
Copyright: © 2016 Manuscript Technomedia. This is an open access article.
- Published:
- Mar 2, 2016
- Received:
- May 21, 2015
How to cite
Weon, J. B., Jung, Y. S., & Ma, C. J. (2016). Quality Analysis of Chlorogenic Acid and Hyperoside in Crataegi fructus. Pharmacognosy Magazine, 12(46), 98–103. https://doi.org/10.4103/0973-1296.177904
Abstract
Background: Crataegi fructus is a herbal medicine for strong stomach, sterilization, and alcohol detoxification. Chlorogenic acid and hyperoside are the major compounds in Crataegi fructus. Objective: In this study, we established novel high‑performance liquid chromatography (HPLC)‑diode array detection analysis method of chlorogenic acid and hyperoside for quality control of Crataegi fructus. Materials and Methods: HPLC analysis was achieved on a reverse‑phase C18 column (5 μm, 4.6 mm × 250 mm) using water and acetonitrile as mobile phase with gradient system. The method was validated for linearity, precision, and accuracy. About 31 batches of Crataegi fructus samples collected from Korea and China were analyzed by using HPLC fingerprint of developed HPLC method. Then, the contents of chlorogenic acid and hyperoside were compared for quality evaluation of Crataegi fructus. Results: The results have shown that the average contents (w/w %) of chlorogenic acid and hyperoside in Crataegi fructus collected from Korea were 0.0438% and 0.0416%, respectively, and the average contents (w/w %) of 0.0399% and 0.0325%, respectively. Conclusion: In conclusion, established HPLC analysis method was stable and could provide efficient quality evaluation for monitoring of commercial Crataegi fructus.
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Article metadata
| Title | Quality Analysis of Chlorogenic Acid and Hyperoside in Crataegi fructus |
|---|---|
| Authors | Jin Bae Weon; Youn Sik Jung; Choong Je Ma |
| Affiliations | Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University.; Department of Biomaterials Engineering, Kangwon National University, Chuncheon 200‑701, Korea. |
| Corresponding author | cjma@kangwon.ac.kr |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 12, Issue 46 (2016) |
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