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Original ArticlePharmacognosy MagazineVol. 14 | Issue 56 | 2018 | pp. 461–464Open access
Peroxisome Proliferator‑Activated Receptor‑γ Agonistic Effect of Chrysanthemum indicum Capitulum and Its Active Ingredients
- 1,
- 2,
- 1,
- 3,
- 2,
- 1*
- 1 Department of Pharmacognosy, School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467‑8603, Japan.
- 2 Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467‑8603, Japan.
- 3 Department of Health Chemistry, School of Pharmacy, Iwate Medical University, Morioka 020‑0023, Japan.
Published in Pharmacognosy Magazine
Correspondence: Toshiaki Makino
Department of Pharmacognosy, School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467‑8603, Japan.
Email: makino@phar.nagoya‑cu.ac.jp
Copyright: © 2018 Manuscript Technomedia. This is an open access article.
- Published:
- Aug 14, 2018
- Received:
- Dec 20, 2017
- DOI:
- 10.4103/pm.pm_607_17
How to cite
Zhang, F., Iwaki, A., Ishiuchi, K., Sugiyama, A., Ohsawa, M., & Makino, T. (2018). Peroxisome Proliferator‑Activated Receptor‑γ Agonistic Effect of Chrysanthemum indicum Capitulum and Its Active Ingredients. Pharmacognosy Magazine, 14(56), 461–464. https://doi.org/10.4103/pm.pm_607_17
Abstract
Objective: The capitulum of Chrysanthemum indicum (Compositae) is the source of a crude drug used in Japanese traditional Kampo and traditional Chinese medicine. Previous research showed that C. indicum flowers promote adipocyte differentiation through the activation of peroxisome proliferator‑activated receptor (PPAR)‑γ that may be an important mechanism for controlling systemic insulin resistance or other biological functions. Materials and Methods: The capitulum of C. indicum was extracted with methanol, and its PPAR‑γ agonistic activity was measured using luciferase assay. The active ingredients were isolated by the activity‑guided fractionations. Results: We isolated (Z)‑tonghaosu and (E)‑tonghaosu, and (E)‑tonghaosu had PPAR‑γ agonistic constituents by the activity‑guided fractionation from the capitulum of C. indicum. The isomer (Z)‑tonghaosu did not show PPAR‑γ‑agonistic activity. Conclusion: (E)‑tonghaosu is one of the active ingredients as PPAR‑γ agonist in the capitulum of C. indicum.
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Article metadata
| Title | Peroxisome Proliferator ‑Activated Receptor‑γ Agonistic Effect of Chrysanthemum indicum Capitulum and Its Active Ingredients |
|---|---|
| Authors | Fuzi Zhang; Anna Iwaki; Kan’ichiro Ishiuchi; Akinori Sugiyama; Masahiro Ohsawa; Toshiaki Makino |
| Affiliations | Department of Pharmacognosy, School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467‑8603, Japan.; Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467‑8603, Japan.; Department of Health Chemistry, School of Pharmacy, Iwate Medical University, Morioka 020‑0023, Japan. |
| Corresponding author | makino@phar.nagoya‑cu.ac.jp |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 14, Issue 56 (2018) |
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