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Original ArticlePharmacognosy MagazineVol. 16 | Issue 69 | 2020 | pp. 294–302Open access
Dendrobium officinale Kimura et Migo Improved Dry Eye Symptoms via Promoting Tear Production in an Experimental Dry Eye Rat Model
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- 1 Institute of Chinese Medicine, The Chinese University of Hong Kong, China.
- 2 State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
- 3 Shenzhen Institute of Geriatrics, The First Affiliated Hospital of Shenzhen University (Shenzhen Second People’s Hospital), Shenzhen, Guangdong, China.
- 4 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, China.
Published in Pharmacognosy Magazine
Correspondence: Zheng‑Zhi Wu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, China.
Email: szwzz001@email.szu.edu.cn
Correspondence: Jiang‑Miao Hu
Email: hujiangmiao@mail.kib.ac.cn
Correspondence: Ping‑Chung Leung
State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.; Shenzhen Institute of Geriatrics, The First Affiliated Hospital of Shenzhen University (Shenzhen Second People’s Hospital), Shenzhen, Guangdong, China.
Email: pingcleung@cuhk.edu.hk
Copyright: © 2020 Manuscript Technomedia. This is an open access article.
- Published:
- Jun 15, 2020
- Received:
- Sep 30, 2019
- Accepted:
- Feb 17, 2020
- DOI:
- 10.4103/pm.pm_435_19
How to cite
Zeng, Q., Siu, W., Ko, C., Wong, C., Lau, C. B., Wu, Z., Hu, J., & Leung, P. (2020). Dendrobium officinale Kimura et Migo Improved Dry Eye Symptoms via Promoting Tear Production in an Experimental Dry Eye Rat Model. Pharmacognosy Magazine, 16(69), 294–302. https://doi.org/10.4103/pm.pm_435_19
Abstract
Background: The genus <em>Cissus</em> (Vitaceae) is known for its medicinal properties. <em>Cissus quadrangularis</em> is the most studied species, but other species like <em>Cissus vitiginea</em> L. also possess pharmacological potential. Objective: To evaluate the antioxidant, anti-inflammatory, and anti-arthritic activities of the methanolic extract of <em>Cissus vitiginea</em> (MECV) leaves. Materials and Methods: The antioxidant activity was assessed using DPPH, hydroxyl radical, and superoxide radical scavenging assays. The anti-inflammatory activity was evaluated using the carrageenan-induced rat paw edema model. The anti-arthritic activity was assessed using the adjuvant-induced arthritis model in rats. Results: MECV showed significant antioxidant activity in a dose-dependent manner. In the carrageenan-induced paw edema model, MECV (200 and 400 mg/kg) significantly reduced paw edema. In the adjuvant-induced arthritis model, MECV treatment significantly reduced the paw volume and improved the hematological parameters compared to the arthritic control group. Conclusion: The results suggest that <em>Cissus vitiginea</em> possesses significant antioxidant, anti-inflammatory, and anti-arthritic activities, which could be attributed to the presence of phytochemicals like flavonoids and phenolic compounds.
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Article metadata
| Title | Dendrobium officinale Kimura et Migo Improved Dry Eye Symptoms via Promoting Tear Production in an Experimental Dry Eye Rat Model |
|---|---|
| Authors | Qiang Zeng; Wing‑Sum Siu; Chun‑Hay Ko; Chun‑Wai Wong; Clara Bik‑San Lau; Zheng‑Zhi Wu; Jiang‑Miao Hu; Ping‑Chung Leung |
| Affiliations | Institute of Chinese Medicine, The Chinese University of Hong Kong, China.; State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.; Shenzhen Institute of Geriatrics, The First Affiliated Hospital of Shenzhen University (Shenzhen Second People’s Hospital), Shenzhen, Guangdong, China.; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, China. |
| Corresponding author | szwzz001@email.szu.edu.cn |
| Journal | Pharmacognosy Magazine |
| Volume / Issue | Vol. 16, Issue 69 (2020) |
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